Mybl1 MGI Mouse Gene Detail - MGI:99925 - myeloblastosis oncogene-like 1

Symbol

Mybl1
Name

myeloblastosis oncogene-like 1
Synonyms

A-myb, G1-419-6, repro9

Feature Type

protein coding gene
IDs

MGI:99925
NCBI Gene: 17864
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:9737640-9770434 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 2.08 cM
Mapping Data

3 experiments

SNPs within 2kb

634 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99925	protein coding gene	Chr1:9737632-9770664 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015826	protein coding gene	Chr1:6902739-6936276 (-)
A/J	MGP_AJ_G0015808	protein coding gene	Chr1:6974625-7007421 (-)
AKR/J	MGP_AKRJ_G0015767	protein coding gene	Chr1:6856989-6891072 (-)
BALB/cJ	MGP_BALBcJ_G0015764	protein coding gene	Chr1:6714350-6748385 (-)
C3H/HeJ	MGP_C3HHeJ_G0015598	protein coding gene	Chr1:6780126-6812684 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016218	protein coding gene	Chr1:7241122-7283146 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013939	protein coding gene	Chr1:5827854-5860577 (-)
CAST/EiJ	MGP_CASTEiJ_G0015178	protein coding gene	Chr1:6966225-6999494 (-)
CBA/J	MGP_CBAJ_G0015571	protein coding gene	Chr1:7391975-7424639 (-)
DBA/2J	MGP_DBA2J_G0015670	protein coding gene	Chr1:6602873-6636371 (-)
FVB/NJ	MGP_FVBNJ_G0015675	protein coding gene	Chr1:6518469-6551936 (-)
LP/J	MGP_LPJ_G0015742	protein coding gene	Chr1:7124491-7157184 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015694	protein coding gene	Chr1:8042503-8077815 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016264	protein coding gene	Chr1:6761346-6795375 (-)
PWK/PhJ	MGP_PWKPhJ_G0014962	protein coding gene	Chr1:6459179-6493043 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014742	protein coding gene	Chr1:6927921-6960551 (-)
WSB/EiJ	MGP_WSBEiJ_G0015242	protein coding gene	Chr1:6788046-6823908 (-)

Human Ortholog

MYBL1, MYB proto-oncogene like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYBL1, MYB proto-oncogene like 1
Synonyms

A-MYB, AMYB
Links

HGNC:7547

NCBI Gene ID: 4603

neXtProt AC: NX_P10243

UniProt: P10243
Chr Location

8q13.1; chr8:66562175-66614247 (-) GRCh38

MGI Vertebrate Homology

Mybl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYBL1
Gene Tree

Mybl1

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Phenotype Summary

37 phenotypes from 3 alleles in 4 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice of both sexes show growth retardation after birth and an impairment of serum antibody response. Male mutant mice are sterile due to a meiotic defect. While female mutant mice are fertile, breast development is impaired after pregnancy.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

968
Tissues

214
cDNA Data

26
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mybl1

ZFIN mybl1

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All Sequences

51
RefSeq

10
UniProt

6
CCDS

CCDS35510.1, CCDS69861.1

Ensembl

ENSMUSG00000025912 (Evidence)
NCBI Gene

17864

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025912	Ensembl Gene Model \| MGI Sequence Detail	32795	C57BL/6J	± kb
transcript	ENSMUST00000088658	Ensembl \| MGI Sequence Detail	4980	Not Applicable
polypeptide	ENSMUSP00000086034	Ensembl \| MGI Sequence Detail	751	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010801 Myb-related protein A

(term hierarchy)
InterPro Domains

IPR015395 C-myb, C-terminal

IPR009057 Homeobox-like domain superfamily

IPR017930 Myb domain

IPR050560 MYB Transcription Factors

IPR001005 SANT/Myb domain

IPR012642 Transcription regulator Wos2-domain

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All nucleic 32

Genomic 1

cDNA 27

Primer pair 3

Other 1

Microarray probesets 4

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MGD-MRK-16727, MGI:3512779

Summaries

All 59

Developmental Gene Expression 16

Gene Ontology 7

Phenotypes 20
Earliest

J:20548 Mettus RV, et al., Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene. 1994 Oct;9(10):3077-86
Latest

J:341559 Yu T, et al., A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals. RNA. 2022 Oct 14;29(1):30-43

TSS for Mybl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10929	Chr1:9770618-9770637 (-)	-194 bp
Tssr10928	Chr1:9770568-9770611 (-)	-156 bp
Tssr10927	Chr1:9770542-9770554 (-)	-114 bp
Tssr10926	Chr1:9767088-9767099 (-)	3,340 bp
Tssr10925	Chr1:9755760-9755764 (-)	14,672 bp
Tssr10924	Chr1:9752431-9752433 (-)	18,002 bp
Tssr10923	Chr1:9737925-9737926 (-)	32,508 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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