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Mybl1 Gene Detail
Summary
  • Symbol
    Mybl1
  • Name
    myeloblastosis oncogene-like 1
  • Synonyms
    A-myb, G1-419-6, repro9
  • Feature Type
    protein coding gene
  • IDs
    MGI:99925
    NCBI Gene: 17864
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:9737640-9770434 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 2.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    634 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99925
 protein coding gene Chr1:9737632-9770664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015826
 protein coding gene Chr1:6902739-6936276 (-)
A/J MGP_AJ_G0015808
 protein coding gene Chr1:6974625-7007421 (-)
AKR/J MGP_AKRJ_G0015767
 protein coding gene Chr1:6856989-6891072 (-)
BALB/cJ MGP_BALBcJ_G0015764
 protein coding gene Chr1:6714350-6748385 (-)
C3H/HeJ MGP_C3HHeJ_G0015598
 protein coding gene Chr1:6780126-6812684 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016218
 protein coding gene Chr1:7241122-7283146 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013939
 protein coding gene Chr1:5827854-5860577 (-)
CAST/EiJ MGP_CASTEiJ_G0015178
 protein coding gene Chr1:6966225-6999494 (-)
CBA/J MGP_CBAJ_G0015571
 protein coding gene Chr1:7391975-7424639 (-)
DBA/2J MGP_DBA2J_G0015670
 protein coding gene Chr1:6602873-6636371 (-)
FVB/NJ MGP_FVBNJ_G0015675
 protein coding gene Chr1:6518469-6551936 (-)
LP/J MGP_LPJ_G0015742
 protein coding gene Chr1:7124491-7157184 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015694
 protein coding gene Chr1:8042503-8077815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016264
 protein coding gene Chr1:6761346-6795375 (-)
PWK/PhJ MGP_PWKPhJ_G0014962
 protein coding gene Chr1:6459179-6493043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014742
 protein coding gene Chr1:6927921-6960551 (-)
WSB/EiJ MGP_WSBEiJ_G0015242
 protein coding gene Chr1:6788046-6823908 (-)



Homology
more
  • Human Ortholog
    MYBL1, MYB proto-oncogene like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYBL1, MYB proto-oncogene like 1
  • Synonyms
    A-MYB, AMYB
  • Links
    NCBI Gene ID: 4603
    neXtProt AC: NX_P10243
    UniProt: P10243

  • Chr Location
    8q13.1; chr8:66562175-66614247 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice of both sexes show growth retardation after birth and an impairment of serum antibody response. Male mutant mice are sterile due to a meiotic defect. While female mutant mice are fertile, breast development is impaired after pregnancy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    214
  • cDNA Data
    26
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025912 Ensembl Gene Model | MGI Sequence Detail 32795 C57BL/6J ±  kb
    transcript ENSMUST00000088658 Ensembl | MGI Sequence Detail 4980 Not Applicable  
    polypeptide ENSMUSP00000086034 Ensembl | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 1
      cDNA 27
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16727, MGI:3512779
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 16
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:20548 Mettus RV, et al., Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene. 1994 Oct;9(10):3077-86
    • Latest
      J:341559 Yu T, et al., A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals. RNA. 2022 Oct 14;29(1):30-43
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory