Mafk MGI Mouse Gene Detail - MGI:99951 - v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)

Symbol

Mafk
Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
Synonyms

NF-E2, Nfe2u, p18 NF-E2

Feature Type

protein coding gene
IDs

MGI:99951
NCBI Gene: 17135
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:139777291-139788409 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 78.81 cM
Mapping Data

12 experiments

SNPs within 2kb

321 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99951	protein coding gene	Chr5:139777268-139788409 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030290	protein coding gene	Chr5:144809489-144820602 (+)
A/J	MGP_AJ_G0030259	protein coding gene	Chr5:138657653-138668801 (+)
AKR/J	MGP_AKRJ_G0030191	protein coding gene	Chr5:142986481-142997615 (+)
BALB/cJ	MGP_BALBcJ_G0030276	protein coding gene	Chr5:139901983-139914250 (+)
C3H/HeJ	MGP_C3HHeJ_G0029987	protein coding gene	Chr5:143760091-143771200 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030721	protein coding gene	Chr5:150155878-150167019 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027939	protein coding gene	Chr5:132512892-132523986 (+)
CAST/EiJ	MGP_CASTEiJ_G0029392	protein coding gene	Chr5:143174797-143186933 (+)
CBA/J	MGP_CBAJ_G0029957	protein coding gene	Chr5:156350661-156361771 (+)
DBA/2J	MGP_DBA2J_G0030107	protein coding gene	Chr5:138470084-138481235 (+)
FVB/NJ	MGP_FVBNJ_G0030062	protein coding gene	Chr5:137598575-137609714 (+)
LP/J	MGP_LPJ_G0030193	protein coding gene	Chr5:145421919-145434238 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030093	protein coding gene	Chr5:158971498-158982690 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030761	protein coding gene	Chr5:142820747-142831894 (+)
PWK/PhJ	MGP_PWKPhJ_G0029107	protein coding gene	Chr5:137486296-137497312 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028943	protein coding gene	Chr5:140493624-140504959 (+)
WSB/EiJ	MGP_WSBEiJ_G0029466	protein coding gene	Chr5:143580167-143591305 (+)

Human Ortholog

MAFK, MAF bZIP transcription factor K

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAFK, MAF bZIP transcription factor K
Synonyms

NFE2U, P18
Links

HGNC:6782

NCBI Gene ID: 7975

neXtProt AC: NX_O60675

UniProt: O60675
Chr Location

7p22.3; chr7:1530702-1543043 (+) GRCh38

MGI Vertebrate Homology

Mafk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAFK
Gene Tree

Mafk

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotypes from multigenic genotypes
20 phenotype references

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

1
Targeted

6
Transgenic

2
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile, healthy and phenotypically normal with no detectable erythroid deficiencies.

less

All GO Annotations

23
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

117
cDNA Data

46
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAFK

Xenbase mafk

ZFIN mafk

less

All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS19814.1

Ensembl

ENSMUSG00000018143 (Evidence)
NCBI Gene

17135

			Length	Strain/Species	Flank
genomic	17135	NCBI Gene Model \| MGI Sequence Detail	11119	C57BL/6J	± kb
transcript	NM_010757	RefSeq \| MGI Sequence Detail	2825	ZRU/MplStud
polypeptide	Q61827	UniProt \| EBI \| MGI Sequence Detail	156	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000010051 transcription factor MafK

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR046347 Basic-leucine zipper domain superfamily

IPR024874 Transcription factor Maf family

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
GlyGen

Q61827 5 sites, 1 O-linked glycan (5 sites)

less

All nucleic 58

Genomic 4

cDNA 46

Primer pair 7

Other 1

Microarray probesets 3

less

MGD-MRK-12104, MGD-MRK-16754, MGI:2141147

Summaries

All 71

Developmental Gene Expression 16

Gene Ontology 10

Phenotypes 20
Earliest

J:20799 Andrews NC, et al., The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92
Latest

J:328989 Patel SD, et al., Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893

TSS for Mafk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49526	Chr5:139777263-139777272 (+)	-23 bp
Tssr49527	Chr5:139777277-139777294 (+)	-5 bp
Tssr49528	Chr5:139777311-139777356 (+)	43 bp
Tssr49529	Chr5:139779749-139779760 (+)	2,464 bp
Tssr49530	Chr5:139786767-139786772 (+)	9,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24