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Ewsr1 Gene Detail
Summary
  • Symbol
    Ewsr1
  • Name
    Ewing sarcoma breakpoint region 1
  • Synonyms
    Ews
  • Feature Type
    protein coding gene
  • IDs
    MGI:99960
    NCBI Gene: 14030
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5019689-5049266 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.22 cM, cytoband A1-A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99960
 protein coding gene Chr11:5019687-5049314 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017996
 protein coding gene Chr11:2089780-2122264 (-)
A/J MGP_AJ_G0017969
 protein coding gene Chr11:2027756-2059228 (-)
AKR/J MGP_AKRJ_G0017933
 protein coding gene Chr11:2122993-2158662 (-)
BALB/cJ MGP_BALBcJ_G0017937
 protein coding gene Chr11:1999697-2037227 (-)
C3H/HeJ MGP_C3HHeJ_G0017750
 protein coding gene Chr11:2012670-2057480 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018389
 protein coding gene Chr11:2161485-2192938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016047
 protein coding gene Chr11:1922902-1952846 (-)
CAST/EiJ MGP_CASTEiJ_G0017312
 protein coding gene Chr11:1988602-2017860 (-)
CBA/J MGP_CBAJ_G0017725
 protein coding gene Chr11:2455299-2495483 (-)
DBA/2J MGP_DBA2J_G0017835
 protein coding gene Chr11:1927780-1958274 (-)
FVB/NJ MGP_FVBNJ_G0017827
 protein coding gene Chr11:1965860-1998650 (-)
LP/J MGP_LPJ_G0017906
 protein coding gene Chr11:2165130-2201048 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017853
 protein coding gene Chr11:2086972-2119130 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018429
 protein coding gene Chr11:2123249-2158321 (-)
PWK/PhJ MGP_PWKPhJ_G0017092
 protein coding gene Chr11:1944456-1976265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016889
 protein coding gene Chr11:2115609-2145385 (-)
WSB/EiJ MGP_WSBEiJ_G0017366
 protein coding gene Chr11:1994093-2026785 (-)



Homology
more
  • Human Ortholog
    EWSR1, EWS RNA binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EWSR1, EWS RNA binding protein 1
  • Synonyms
    bK984G1.4, EWS, EWS-FLI1
  • Links
    NCBI Gene ID: 2130
    neXtProt AC: NX_Q01844
    UniProt: Q01844

  • Chr Location
    22q12.2; chr22:29268009-29300525 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EWSR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    35 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit postnatal lethality, defective pre-B cell development, apoptosis of gametes and arrest in gamete maturation due to reduced meiotic recombination leading to infertility, kyphosis, lymphopenia, muscular atrophy, and hypersensitivity to ionizing radiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    114
  • cDNA Data
    330
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009079 Ensembl Gene Model | MGI Sequence Detail 29578 C57BL/6J ±  kb
    transcript ENSMUST00000102930 Ensembl | MGI Sequence Detail 2174 Not Applicable  
    polypeptide ENSMUSP00000099994 Ensembl | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 339
      cDNA 330
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16765, MGI:2146130
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 16
      Gene Ontology 12
      Phenotypes 34
    • Earliest
      J:20151 Plougastel B, et al., Cloning and chromosome localization of the mouse Ews gene. Genomics. 1994 Sep 1;23(1):278-81
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory