GO Annotations Graph

• Symbol: Cfl1
• Name: cofilin 1, non-muscle
• ID: MGI:101757

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	IDA	J:233587
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:1902936	phosphatidylinositol bisphosphate binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:276268
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:201126
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0031252	cell leading edge	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0090732	cofilin-actin rod	ISO	J:155856
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:91448
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:97332
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:97332
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-482767
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-421139
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-482767
Cellular Component	GO:0030175	filopodium	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:254431
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	IDA	J:243478
Cellular Component	GO:0030027	lamellipodium	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Biological Process	GO:0030042	actin filament depolymerization	IDA	J:233587
Biological Process	GO:0030042	actin filament depolymerization	ISO	J:164563
Biological Process	GO:0030043	actin filament fragmentation	IDA	J:233587
Biological Process	GO:0030043	actin filament fragmentation	IBA	J:265628
Biological Process	GO:0007015	actin filament organization	IMP	J:276268
Biological Process	GO:0007015	actin filament organization	IMP	J:96452
Biological Process	GO:0051014	actin filament severing	IBA	J:265628
Biological Process	GO:0030030	cell projection organization	ISO	J:103933
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:155856
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	ISO	J:155856
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:155856
Biological Process	GO:0071354	cellular response to interleukin-6	ISO	J:155856
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0007010	cytoskeleton organization	ISO	J:164563
Biological Process	GO:0030010	establishment of cell polarity	IMP	J:96452
Biological Process	GO:0051293	establishment of spindle localization	IMP	J:276268
Biological Process	GO:0000281	mitotic cytokinesis	IBA	J:265628
Biological Process	GO:0000281	mitotic cytokinesis	IMP	J:97332
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	ISO	J:155856
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	ISO	J:155856
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:155856
Biological Process	GO:2000146	negative regulation of cell motility	ISO	J:155856
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:103933
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	ISO	J:155856
Biological Process	GO:0010593	negative regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:1905875	negative regulation of postsynaptic density organization	ISO	J:155856
Biological Process	GO:0051511	negative regulation of unidimensional cell growth	ISO	J:155856
Biological Process	GO:0001755	neural crest cell migration	IMP	J:96452
Biological Process	GO:0001842	neural fold formation	IMP	J:96452
Biological Process	GO:0044794	positive regulation by host of viral process	ISO	J:164563
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	IDA	J:207250
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	IMP	J:97332
Biological Process	GO:2000814	positive regulation of barbed-end actin filament capping	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:2000147	positive regulation of cell motility	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0040019	positive regulation of embryonic development	IMP	J:276268
Biological Process	GO:2000784	positive regulation of establishment of cell polarity regulating cell shape	ISO	J:155856
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	ISO	J:155856
Biological Process	GO:1905873	positive regulation of protein localization to cell leading edge	ISO	J:155856
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:155856
Biological Process	GO:0031915	positive regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0006606	protein import into nucleus	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:116055
Biological Process	GO:0022604	regulation of cell morphogenesis	ISO	J:164563
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	ISO	J:164563
Biological Process	GO:0043200	response to amino acid	IDA	J:116055