GO Annotations Graph

• Symbol: Hmga2
• Name: high mobility group AT-hook 2
• ID: MGI:101761

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051575	5'-deoxyribose-5-phosphate lyase activity	ISO	J:164563
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	ISO	J:164563
Molecular Function	GO:0035497	cAMP response element binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0008301	DNA binding, bending	ISO	J:164563
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:146612
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0035501	MH1 domain binding	ISO	J:164563
Molecular Function	GO:0035500	MH2 domain binding	ISO	J:164563
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	ISO	J:164563
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	IDA	J:101650
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0031492	nucleosomal DNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:110132
Molecular Function	GO:0005515	protein binding	IPI	J:90007
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IEA	J:72247
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:90007
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:126188
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:90007
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:126188
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:126188
Cellular Component	GO:0000228	nuclear chromosome	IDA	J:71817
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:126188
Cellular Component	GO:0005634	nucleus	IDA	J:121712
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	ISO	J:164563
Cellular Component	GO:0071141	SMAD protein complex	ISO	J:164563
Biological Process	GO:0060612	adipose tissue development	IMP	J:21153
Biological Process	GO:0030325	adrenal gland development	IMP	J:21153
Biological Process	GO:0048708	astrocyte differentiation	IDA	J:140867
Biological Process	GO:0048708	astrocyte differentiation	IDA	J:140867
Biological Process	GO:0006284	base-excision repair	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IMP	J:144068
Biological Process	GO:0021846	cell proliferation in forebrain	IMP	J:144068
Biological Process	GO:0021846	cell proliferation in forebrain	IMP	J:144068
Biological Process	GO:0002062	chondrocyte differentiation	ISO	J:164563
Biological Process	GO:0035988	chondrocyte proliferation	ISO	J:164563
Biological Process	GO:0030261	chromosome condensation	IEA	J:60000
Biological Process	GO:0035987	endodermal cell differentiation	ISO	J:164563
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	IMP	J:221285
Biological Process	GO:0045444	fat cell differentiation	ISO	J:164563
Biological Process	GO:0060613	fat pad development	IGI	J:61493
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:28571
Biological Process	GO:0031507	heterochromatin formation	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0060428	lung epithelium development	IMP	J:221285
Biological Process	GO:0008584	male gonad development	IMP	J:21153
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0048762	mesenchymal cell differentiation	ISO	J:164563
Biological Process	GO:0048333	mesodermal cell differentiation	ISO	J:164563
Biological Process	GO:0003131	mesodermal-endodermal cell signaling	ISO	J:164563
Biological Process	GO:0043922	negative regulation by host of viral transcription	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	IDA	J:140867
Biological Process	GO:2000773	negative regulation of cellular senescence	IMP	J:212874
Biological Process	GO:0043392	negative regulation of DNA binding	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	ISO	J:155856
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IMP	J:221285
Biological Process	GO:0090402	oncogene-induced cell senescence	ISO	J:164563
Biological Process	GO:0021983	pituitary gland development	IMP	J:6231
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:212874
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:144068
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	IMP	J:212874
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP	J:221285
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:28571
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:91358
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:5290
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:21153
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:28571
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:13064
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	MGI:MGI:61256
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:2000648	positive regulation of stem cell proliferation	ISO	J:164563
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:144068
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:221285
Biological Process	GO:0010564	regulation of cell cycle process	IDA	J:175196
Biological Process	GO:0010564	regulation of cell cycle process	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0060123	regulation of growth hormone secretion	IMP	J:6231
Biological Process	GO:0090276	regulation of peptide hormone secretion	IMP	J:6231
Biological Process	GO:2000036	regulation of stem cell population maintenance	ISO	J:164563
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:144068
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:144068
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:144068
Biological Process	GO:0007283	spermatogenesis	IMP	J:126188
Biological Process	GO:0072089	stem cell proliferation	IMP	J:144068