GO Annotations Graph

• Symbol: Cfl2
• Name: cofilin 2, muscle
• ID: MGI:101763

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	IDA	J:233587
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0031674	I band	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Biological Process	GO:0030042	actin filament depolymerization	ISO	J:164563
Biological Process	GO:0030042	actin filament depolymerization	IDA	J:233587
Biological Process	GO:0030042	actin filament depolymerization	IDA	J:211364
Biological Process	GO:0030042	actin filament depolymerization	IGI	J:211364
Biological Process	GO:0030043	actin filament fragmentation	IDA	J:233587
Biological Process	GO:0030043	actin filament fragmentation	IBA	J:265628
Biological Process	GO:0007015	actin filament organization	IMP	J:182571
Biological Process	GO:0051014	actin filament severing	IBA	J:265628
Biological Process	GO:0046716	muscle cell cellular homeostasis	IMP	J:182571
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	ISO	J:164563
Biological Process	GO:0045214	sarcomere organization	IMP	J:182571
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:233564