GO Annotations Graph

• Symbol: Cdk5r1
• Name: cyclin dependent kinase 5, regulatory subunit 1
• ID: MGI:101764

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IPI	J:144029
Molecular Function	GO:0051015	actin filament binding	IPI	J:144029
Molecular Function	GO:0045296	cadherin binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	ISO	J:155856
Molecular Function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	IBA	J:265628
Molecular Function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	IMP	J:71181
Molecular Function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	TAS	J:80857
Molecular Function	GO:0008092	cytoskeletal protein binding	TAS	J:80587
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:155856
Molecular Function	GO:0051879	Hsp90 protein binding	IPI	J:259130
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	IPI	J:144029
Molecular Function	GO:0016301	kinase activity	ISO	J:155856
Molecular Function	GO:0002020	protease binding	IPI	J:144029
Molecular Function	GO:0005515	protein binding	IPI	J:245337
Molecular Function	GO:0005515	protein binding	IPI	J:117343
Molecular Function	GO:0005515	protein binding	IPI	J:201251
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:212985
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:89612
Molecular Function	GO:0005515	protein binding	IPI	J:95153
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:80587
Molecular Function	GO:0005515	protein binding	IPI	J:124168
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IPI	J:144029
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0043292	contractile fiber	ISO	J:155856
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:201251
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:121046
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8863416
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868331
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868583
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868589
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-8870566
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8868356
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8868383
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:89612
Cellular Component	GO:0005634	nucleus	IDA	J:124168
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8863416
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9634937
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0016533	protein kinase 5 complex	ISO	J:164563
Cellular Component	GO:0016533	protein kinase 5 complex	ISO	J:164563
Cellular Component	GO:0016533	protein kinase 5 complex	ISO	J:155856
Cellular Component	GO:0016533	protein kinase 5 complex	IPI	J:201251
Biological Process	GO:0007411	axon guidance	IMP	J:58359
Biological Process	GO:0007413	axonal fasciculation	IMP	J:58359
Biological Process	GO:0007420	brain development	IMP	J:58359
Biological Process	GO:0007420	brain development	IBA	J:265628
Biological Process	GO:0021549	cerebellum development	IMP	J:67864
Biological Process	GO:0021549	cerebellum development	IGI	J:71181
Biological Process	GO:0021799	cerebral cortex radially oriented cell migration	IMP	J:163156
Biological Process	GO:0009792	embryo development ending in birth or egg hatching	ISO	J:155856
Biological Process	GO:0048013	ephrin receptor signaling pathway	IMP	J:117343
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0070315	G1 to G0 transition involved in cell differentiation	IMP	J:203098
Biological Process	GO:0021766	hippocampus development	IGI	J:71181
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0021819	layer formation in cerebral cortex	IGI	J:71181
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0007158	neuron cell-cell adhesion	IMP	J:113919
Biological Process	GO:0030182	neuron differentiation	ISO	J:155856
Biological Process	GO:0001764	neuron migration	IDA	J:38857
Biological Process	GO:0001764	neuron migration	IGI	J:67864
Biological Process	GO:0001764	neuron migration	IGI	J:71181
Biological Process	GO:0001764	neuron migration	IGI	J:67864
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IGI	J:71181
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IDA	J:169741
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IMP	J:163156
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	IMP	J:117343
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	IMP	J:163156
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0042501	serine phosphorylation of STAT protein	IDA	J:89612
Biological Process	GO:0021722	superior olivary nucleus maturation	IGI	J:71181