Cdk5 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cdk5
cyclin dependent kinase 5
MGI:101765

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030549	acetylcholine receptor activator activity	IDA	J:114070
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:155856
Molecular Function	GO:0005176	ErbB-2 class receptor binding	IDA	J:114070
Molecular Function	GO:0043125	ErbB-3 class receptor binding	IDA	J:114070
Molecular Function	GO:0035173	histone kinase activity	ISO	J:155856
Molecular Function	GO:0051879	Hsp90 protein binding	IPI	J:259130
Molecular Function	GO:0016301	kinase activity	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	IPI	J:124168
Molecular Function	GO:0005515	protein binding	IPI	J:201251
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:245337
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:215912
Molecular Function	GO:0005515	protein binding	IPI	J:144029
Molecular Function	GO:0005515	protein binding	IPI	J:89612
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:169741
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:80587
Molecular Function	GO:0005515	protein binding	IPI	J:85759
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	IDA	J:119083
Molecular Function	GO:0004672	protein kinase activity	IDA	J:40391
Molecular Function	GO:0004672	protein kinase activity	IDA	J:71181
Molecular Function	GO:0004672	protein kinase activity	IDA	J:121046
Molecular Function	GO:0004672	protein kinase activity	IDA	J:77532
Molecular Function	GO:0004672	protein kinase activity	IMP	J:102479
Molecular Function	GO:0004672	protein kinase activity	ISO	J:120888
Molecular Function	GO:0004672	protein kinase activity	IMP	J:169741
Molecular Function	GO:0004672	protein kinase activity	IMP	J:88431
Molecular Function	GO:0004672	protein kinase activity	IDA	J:41229
Molecular Function	GO:0004672	protein kinase activity	IDA	J:67864
Molecular Function	GO:0004672	protein kinase activity	IDA	J:107755
Molecular Function	GO:0004672	protein kinase activity	IDA	J:69136
Molecular Function	GO:0004672	protein kinase activity	IMP	J:102479
Molecular Function	GO:0004672	protein kinase activity	IMP	J:169741
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-8868356
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-8868383
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:85235
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:169741
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:95153
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:169741
Molecular Function	GO:0050321	tau-protein kinase activity	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:36350
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:201251
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:89612
Cellular Component	GO:0005737	cytoplasm	IDA	J:40995
Cellular Component	GO:0005737	cytoplasm	IDA	J:36350
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1013873
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868331
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868583
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868589
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9634923
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-421136
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-8870566
Cellular Component	GO:0005829	cytosol	IDA	J:41229
Cellular Component	GO:0005829	cytosol	IDA	J:80587
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030175	filopodium	IDA	J:80587
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	IDA	J:80587
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8868356
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8868383
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:40995
Cellular Component	GO:0005634	nucleus	IDA	J:89612
Cellular Component	GO:0005634	nucleus	IDA	J:124168
Cellular Component	GO:0005634	nucleus	IDA	J:35360
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0016533	protein kinase 5 complex	ISO	J:155856
Cellular Component	GO:0016533	protein kinase 5 complex	IPI	J:201251
Cellular Component	GO:0016533	protein kinase 5 complex	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IDA	J:40391
Biological Process	GO:0008306	associative learning	IMP	J:76252
Biological Process	GO:0007409	axonogenesis	IBA	J:265628
Biological Process	GO:0007409	axonogenesis	IMP	J:66487
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:127641
Biological Process	GO:0070509	calcium ion import	IMP	J:169741
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0016477	cell migration	IDA	J:80587
Biological Process	GO:0016477	cell migration	IMP	J:127421
Biological Process	GO:0016477	cell migration	IMP	J:127644
Biological Process	GO:0007160	cell-matrix adhesion	IDA	J:80587
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:155856
Biological Process	GO:0021954	central nervous system neuron development	IMP	J:64289
Biological Process	GO:0021695	cerebellar cortex development	IMP	J:64289
Biological Process	GO:0021697	cerebellar cortex formation	IMP	J:56295
Biological Process	GO:0021549	cerebellum development	IMP	J:67864
Biological Process	GO:0021987	cerebral cortex development	IMP	J:49501
Biological Process	GO:0022038	corpus callosum development	IMP	J:127644
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:107755
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:117343
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:169741
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:124046
Biological Process	GO:0006887	exocytosis	ISO	J:155856
Biological Process	GO:0030900	forebrain development	IMP	J:127421
Biological Process	GO:0021766	hippocampus development	IMP	J:71181
Biological Process	GO:0006886	intracellular protein transport	IMP	J:64289
Biological Process	GO:0021819	layer formation in cerebral cortex	IMP	J:71181
Biological Process	GO:0007005	mitochondrion organization	ISO	J:155856
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:102479
Biological Process	GO:0030517	negative regulation of axon extension	IGI	J:184851
Biological Process	GO:0045786	negative regulation of cell cycle	IMP	J:102162
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:164563
Biological Process	GO:0046826	negative regulation of protein export from nucleus	IMP	J:124168
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IMP	J:124168
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:164563
Biological Process	GO:0031914	negative regulation of synaptic plasticity	IMP	J:124046
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0051402	neuron apoptotic process	ISO	J:155856
Biological Process	GO:0051402	neuron apoptotic process	IBA	J:265628
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:124168
Biological Process	GO:0030182	neuron differentiation	ISO	J:155856
Biological Process	GO:0030182	neuron differentiation	ISA	J:120888
Biological Process	GO:0030182	neuron differentiation	IMP	J:102162
Biological Process	GO:0001764	neuron migration	IMP	J:89561
Biological Process	GO:0001764	neuron migration	IMP	J:56295
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0006913	nucleocytoplasmic transport	ISO	J:155856
Biological Process	GO:0048709	oligodendrocyte differentiation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:248452
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:169741
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:169741
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:169741
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:248452
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:169741
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0045956	positive regulation of calcium ion-dependent exocytosis	IDA	J:121046
Biological Process	GO:0034352	positive regulation of glial cell apoptotic process	ISO	J:155856
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:0099533	positive regulation of presynaptic cytosolic calcium concentration	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	IMP	J:169741
Biological Process	GO:0045860	positive regulation of protein kinase activity	IMP	J:102479
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IMP	J:169741
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0035418	protein localization to synapse	IMP	J:169741
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IMP	J:124168
Biological Process	GO:0006468	protein phosphorylation	ISO	J:120888
Biological Process	GO:0006468	protein phosphorylation	IGI	J:117672
Biological Process	GO:0006468	protein phosphorylation	IDA	J:119083
Biological Process	GO:0006468	protein phosphorylation	IDA	J:71181
Biological Process	GO:0006468	protein phosphorylation	IDA	J:121046
Biological Process	GO:0006468	protein phosphorylation	IDA	J:107755
Biological Process	GO:0006468	protein phosphorylation	IDA	J:95153
Biological Process	GO:0032801	receptor catabolic process	IMP	J:124046
Biological Process	GO:0043113	receptor clustering	IMP	J:102479
Biological Process	GO:0045055	regulated exocytosis	ISO	J:155856
Biological Process	GO:0030334	regulation of cell migration	IMP	J:85235
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	IMP	J:117343
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IMP	J:102479
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	IMP	J:248452
Biological Process	GO:1905806	regulation of synapse pruning	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IMP	J:248452
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0042220	response to cocaine	IMP	J:88431
Biological Process	GO:0009611	response to wounding	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0014044	Schwann cell development	IMP	J:102479
Biological Process	GO:0019233	sensory perception of pain	IMP	J:119083
Biological Process	GO:0042501	serine phosphorylation of STAT protein	IDA	J:89612
Biological Process	GO:0007519	skeletal muscle tissue development	IDA	J:40995
Biological Process	GO:0007416	synapse assembly	IMP	J:169741
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IMP	J:88431
Biological Process	GO:0035249	synaptic transmission, glutamatergic	IMP	J:88431
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0048489	synaptic vesicle transport	IBA	J:265628
Biological Process	GO:0021537	telencephalon development	IMP	J:127644
Biological Process	GO:0008542	visual learning	IMP	J:124046

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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