GO Annotations Graph

• Symbol: Ryk
• Name: receptor-like tyrosine kinase
• ID: MGI:101766

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005109	frizzled binding	IPI	J:93897
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:213778
Molecular Function	GO:0005515	protein binding	IPI	J:84392
Molecular Function	GO:0005515	protein binding	IPI	J:84392
Molecular Function	GO:0005515	protein binding	IPI	J:84392
Molecular Function	GO:0005515	protein binding	IPI	J:93897
Molecular Function	GO:0005515	protein binding	IPI	J:93897
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	TAS	J:228557
Molecular Function	GO:0042813	Wnt receptor activity	IPI	J:93897
Molecular Function	GO:0042813	Wnt receptor activity	IPI	J:93897
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:142801
Molecular Function	GO:0017147	Wnt-protein binding	TAS	J:228112
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:93897
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:93897
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:109038
Cellular Component	GO:0005737	cytoplasm	IDA	J:142801
Cellular Component	GO:0016020	membrane	IDA	J:142801
Cellular Component	GO:0016020	membrane	IDA	J:52203
Cellular Component	GO:0016020	membrane	IDA	J:21655
Cellular Component	GO:0005634	nucleus	IDA	J:142801
Cellular Component	GO:0005886	plasma membrane	IDA	J:22530
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0048846	axon extension involved in axon guidance	IGI	J:109038
Biological Process	GO:0048846	axon extension involved in axon guidance	IGI	J:109038
Biological Process	GO:0007411	axon guidance	IDA	J:168206
Biological Process	GO:0007411	axon guidance	TAS	J:228112
Biological Process	GO:0007411	axon guidance	IMP	J:109038
Biological Process	GO:0007409	axonogenesis	ISO	J:155856
Biological Process	GO:0007409	axonogenesis	IBA	J:265628
Biological Process	GO:0007409	axonogenesis	IGI	J:93897
Biological Process	GO:0033278	cell proliferation in midbrain	ISO	J:155856
Biological Process	GO:0061643	chemorepulsion of axon	TAS	J:228112
Biological Process	GO:0036518	chemorepulsion of dopaminergic neuron axon	IGI	J:228557
Biological Process	GO:0071679	commissural neuron axon guidance	IMP	J:109038
Biological Process	GO:0071679	commissural neuron axon guidance	IMP	J:109038
Biological Process	GO:0022038	corpus callosum development	IMP	J:109038
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	IMP	J:228557
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0050919	negative chemotaxis	IGI	J:109038
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IGI	J:109038
Biological Process	GO:0030182	neuron differentiation	IDA	J:142801
Biological Process	GO:0031175	neuron projection development	IMP	J:93897
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1904938	planar cell polarity pathway involved in axon guidance	IGI	J:228557
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:84392
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:93897
Biological Process	GO:0016055	Wnt signaling pathway	IGI	J:109038
Biological Process	GO:0016055	Wnt signaling pathway	IGI	J:109038
Biological Process	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	ISO	J:155856