GO Annotations Graph

• Symbol: Mcl1
• Name: myeloid cell leukemia sequence 1
• ID: MGI:101769

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051400	BH domain binding	ISO	J:155856
Molecular Function	GO:0051434	BH3 domain binding	ISO	J:164563
Molecular Function	GO:0051434	BH3 domain binding	IPI	J:114727
Molecular Function	GO:0015267	channel activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:201566
Molecular Function	GO:0005515	protein binding	IPI	J:114705
Molecular Function	GO:0005515	protein binding	IPI	J:114727
Molecular Function	GO:0005515	protein binding	IPI	J:163471
Molecular Function	GO:0005515	protein binding	IPI	J:182384
Molecular Function	GO:0005515	protein binding	IPI	J:182474
Molecular Function	GO:0005515	protein binding	IPI	J:173142
Molecular Function	GO:0005515	protein binding	IPI	J:235310
Molecular Function	GO:0005515	protein binding	IPI	J:168877
Molecular Function	GO:0005515	protein binding	IPI	J:203396
Molecular Function	GO:0005515	protein binding	IPI	J:248256
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0097136	Bcl-2 family protein complex	ISO	J:164563
Cellular Component	GO:0097136	Bcl-2 family protein complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:186356
Cellular Component	GO:0005829	cytosol	IDA	J:201566
Cellular Component	GO:0016020	membrane	IDA	J:201566
Cellular Component	GO:0016020	membrane	ISO	J:23788
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IDA	J:204747
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:23788
Cellular Component	GO:0005739	mitochondrion	IDA	J:199864
Cellular Component	GO:0005634	nucleus	IDA	J:186356
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	ISO	J:73065
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:201566
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IDA	J:114727
Biological Process	GO:0008053	mitochondrial fusion	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:182384
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:204747
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0001836	release of cytochrome c from mitochondria	IBA	J:265628
Biological Process	GO:0034097	response to cytokine	ISO	J:40789