GO Annotations Graph

• Symbol: F2r
• Name: coagulation factor II thrombin receptor
• ID: MGI:101802

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IMP	J:175344
Molecular Function	GO:0001965	G-protein alpha-subunit binding	IDA	J:175344
Molecular Function	GO:0031681	G-protein beta-subunit binding	IDA	J:175344
Molecular Function	GO:0032795	heterotrimeric G-protein binding	TAS	J:175344
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0015057	thrombin-activated receptor activity	ISO	J:164563
Molecular Function	GO:0015057	thrombin-activated receptor activity	IBA	J:265628
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0031094	platelet dense tubular network	ISO	J:164563
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007596	blood coagulation	IEA	J:60000
Biological Process	GO:0007596	blood coagulation	IEA	J:72247
Biological Process	GO:0045217	cell-cell junction maintenance	ISO	J:164563
Biological Process	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	ISO	J:164563
Biological Process	GO:0036145	dendritic cell homeostasis	IMP	J:133917
Biological Process	GO:0007529	establishment of synaptic specificity at neuromuscular junction	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:133917
Biological Process	GO:0006954	inflammatory response	IMP	J:133917
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0003105	negative regulation of glomerular filtration	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1900134	negative regulation of renin secretion into blood stream	IDA	J:182471
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030168	platelet activation	ISO	J:164563
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0030194	positive regulation of blood coagulation	IBA	J:265628
Biological Process	GO:0030194	positive regulation of blood coagulation	IMP	J:133917
Biological Process	GO:0030194	positive regulation of blood coagulation	IMP	J:133917
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IDA	J:175344
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA	J:175344
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISO	J:155856
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:175344
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:175344
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:139818
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	IDA	J:175344
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	IDA	J:182471
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030193	regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0032651	regulation of interleukin-1 beta production	IMP	J:133917
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:133917
Biological Process	GO:0009611	response to wounding	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	IGI	J:139818
Biological Process	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP	J:237680