GO Annotations Graph

• Symbol: Msh2
• Name: mutS homolog 2
• ID: MGI:101816

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	IMP	J:86278
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ISO	J:164563
Molecular Function	GO:0140664	ATP-dependent DNA damage sensor activity	IEA	J:72247
Molecular Function	GO:0019237	centromeric DNA binding	IDA	J:104493
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003684	damaged DNA binding	IMP	J:27469
Molecular Function	GO:0003684	damaged DNA binding	IMP	J:59561
Molecular Function	GO:0032139	dinucleotide insertion or deletion binding	ISO	J:164563
Molecular Function	GO:0032181	dinucleotide repeat insertion binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IMP	J:59561
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:164563
Molecular Function	GO:0032137	guanine/thymine mispair binding	ISO	J:164563
Molecular Function	GO:0032137	guanine/thymine mispair binding	ISO	J:111285
Molecular Function	GO:0032137	guanine/thymine mispair binding	IDA	J:111285
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0030983	mismatched DNA binding	ISO	J:164563
Molecular Function	GO:0030983	mismatched DNA binding	IBA	J:265628
Molecular Function	GO:0030983	mismatched DNA binding	IMP	J:28397
Molecular Function	GO:0030983	mismatched DNA binding	IMP	J:88092
Molecular Function	GO:0032405	MutLalpha complex binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0032357	oxidized purine DNA binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0032142	single guanine insertion binding	ISO	J:164563
Molecular Function	GO:0032143	single thymine insertion binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0032300	mismatch repair complex	IEA	J:72247
Cellular Component	GO:0032301	MutSalpha complex	ISO	J:164563
Cellular Component	GO:0032301	MutSalpha complex	IBA	J:265628
Cellular Component	GO:0032301	MutSalpha complex	IDA	J:111285
Cellular Component	GO:0032302	MutSbeta complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:45433
Cellular Component	GO:0005634	nucleus	IC	J:27469
Cellular Component	GO:0005634	nucleus	IC	J:27469
Cellular Component	GO:0005634	nucleus	IC	J:27469
Cellular Component	GO:0005634	nucleus	IDA	J:88092
Biological Process	GO:0030183	B cell differentiation	IMP	J:48834
Biological Process	GO:0019724	B cell mediated immunity	IMP	J:52568
Biological Process	GO:0019724	B cell mediated immunity	IMP	J:48834
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:59561
Biological Process	GO:0006974	DNA damage response	IMP	J:61261
Biological Process	GO:0006974	DNA damage response	IMP	J:70198
Biological Process	GO:0006974	DNA damage response	IMP	J:88092
Biological Process	GO:0006974	DNA damage response	IMP	J:54082
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IMP	J:84394
Biological Process	GO:0006302	double-strand break repair	IMP	J:130019
Biological Process	GO:0007281	germ cell development	IMP	J:130019
Biological Process	GO:0001701	in utero embryonic development	IGI	J:42723
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:88092
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:54082
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:54082
Biological Process	GO:0045190	isotype switching	IMP	J:56764
Biological Process	GO:0045190	isotype switching	IMP	J:83489
Biological Process	GO:0043570	maintenance of DNA repeat elements	ISO	J:164563
Biological Process	GO:0008584	male gonad development	IMP	J:130019
Biological Process	GO:0006298	mismatch repair	ISO	J:164563
Biological Process	GO:0006298	mismatch repair	IBA	J:265628
Biological Process	GO:0006298	mismatch repair	ISO	J:71822
Biological Process	GO:0006298	mismatch repair	IDA	J:41865
Biological Process	GO:0006298	mismatch repair	IMP	J:48833
Biological Process	GO:0006298	mismatch repair	IMP	J:27469
Biological Process	GO:0006298	mismatch repair	IMP	J:65384
Biological Process	GO:0006298	mismatch repair	IMP	J:192085
Biological Process	GO:0006298	mismatch repair	IMP	J:42723
Biological Process	GO:0006298	mismatch repair	IMP	J:75218
Biological Process	GO:0006298	mismatch repair	IDA	J:40423
Biological Process	GO:0006298	mismatch repair	ISO	J:198961
Biological Process	GO:0006298	mismatch repair	IMP	J:115827
Biological Process	GO:0006298	mismatch repair	IMP	J:79732
Biological Process	GO:0006298	mismatch repair	IMP	J:63445
Biological Process	GO:0006298	mismatch repair	IMP	J:119981
Biological Process	GO:0006298	mismatch repair	IGI	J:115827
Biological Process	GO:0006298	mismatch repair	IMP	J:34940
Biological Process	GO:0006298	mismatch repair	IMP	J:88092
Biological Process	GO:0006298	mismatch repair	IMP	J:58797
Biological Process	GO:0006298	mismatch repair	IMP	J:64667
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	IGI	J:94447
Biological Process	GO:0006312	mitotic recombination	IBA	J:265628
Biological Process	GO:0045910	negative regulation of DNA recombination	ISO	J:164563
Biological Process	GO:0045910	negative regulation of DNA recombination	IMP	J:59561
Biological Process	GO:0045910	negative regulation of DNA recombination	IMP	J:27469
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:110435
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:110435
Biological Process	GO:0006119	oxidative phosphorylation	IMP	J:110435
Biological Process	GO:0006119	oxidative phosphorylation	IMP	J:110435
Biological Process	GO:0051096	positive regulation of helicase activity	ISO	J:164563
Biological Process	GO:0048298	positive regulation of isotype switching to IgA isotypes	IMP	J:56764
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP	J:56764
Biological Process	GO:0006301	postreplication repair	ISO	J:164563
Biological Process	GO:0006301	postreplication repair	IMP	J:27469
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:84394
Biological Process	GO:0010224	response to UV-B	IMP	J:93629
Biological Process	GO:0010165	response to X-ray	IMP	J:84394
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:48834
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:86278
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:110877
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IGI	J:94542
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:48833
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:99462
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IGI	J:94542
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:124827
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:86278
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:99207
Biological Process	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	IBA	J:265628
Biological Process	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	IGI	J:83489