GO Annotations Graph

• Symbol: Traf2
• Name: TNF receptor-associated factor 2
• ID: MGI:101835

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005174	CD40 receptor binding	IPI	J:161997
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:169068
Molecular Function	GO:0005515	protein binding	IPI	J:44894
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:173147
Molecular Function	GO:0005515	protein binding	IPI	J:179005
Molecular Function	GO:0005515	protein binding	IPI	J:113841
Molecular Function	GO:0005515	protein binding	IPI	J:54076
Molecular Function	GO:0005515	protein binding	IPI	J:194553
Molecular Function	GO:0005515	protein binding	IPI	J:208867
Molecular Function	GO:0005515	protein binding	IPI	J:209561
Molecular Function	GO:0005515	protein binding	IPI	J:203409
Molecular Function	GO:0005515	protein binding	IPI	J:218005
Molecular Function	GO:0005515	protein binding	IPI	J:245282
Molecular Function	GO:0005515	protein binding	IPI	J:144594
Molecular Function	GO:0005515	protein binding	IPI	J:176472
Molecular Function	GO:0005515	protein binding	IPI	J:136554
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:136554
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0046625	sphingolipid binding	ISO	J:164563
Molecular Function	GO:0031996	thioesterase binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0043120	tumor necrosis factor binding	ISO	J:164563
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:164563
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0035631	CD40 receptor complex	IDA	J:161997
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:209561
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:161997
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:147242
Cellular Component	GO:0005829	cytosol	IDA	J:146389
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	IDA	J:218004
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IDA	J:146389
Cellular Component	GO:0098802	plasma membrane signaling receptor complex	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0097057	TRAF2-GSTP1 complex	ISO	J:164563
Cellular Component	GO:0002947	tumor necrosis factor receptor superfamily complex	ISO	J:164563
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0012506	vesicle membrane	IDA	J:147242
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071732	cellular response to nitric oxide	IMP	J:146389
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IMP	J:176465
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IDA	J:176465
Biological Process	GO:0048255	mRNA stabilization	IMP	J:176465
Biological Process	GO:0043066	negative regulation of apoptotic process	NAS	J:113841
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	ISO	J:155856
Biological Process	GO:0038061	NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:218005
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:1903721	positive regulation of I-kappaB phosphorylation	IDA	J:218005
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IBA	J:265628
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:196113
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:218005
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0002726	positive regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	IDA	J:218005
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:146389
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	IMP	J:86592
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0065003	protein-containing complex assembly	IDA	J:161997
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0002637	regulation of immunoglobulin production	IMP	J:86592
Biological Process	GO:0046328	regulation of JNK cascade	IDA	J:86592
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IDA	J:86592
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IMP	J:176465
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	IDA	J:176465
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IBA	J:265628