GO Annotations Graph

• Symbol: Rack1
• Name: receptor for activated C kinase 1
• ID: MGI:101849

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051434	BH3 domain binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0008200	ion channel inhibitor activity	IDA	J:135325
Molecular Function	GO:0005515	protein binding	IPI	J:135325
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:169104
Molecular Function	GO:0005515	protein binding	IPI	J:211328
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IBA	J:265628
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:66091
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0030292	protein tyrosine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0043022	ribosome binding	ISO	J:164563
Molecular Function	GO:0043022	ribosome binding	IBA	J:265628
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:66091
Cellular Component	GO:0044297	cell body	IDA	J:211328
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:85668
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0030425	dendrite	IDA	J:105896
Cellular Component	GO:1990630	IRE1-RACK1-PP2A complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	IDA	J:211328
Cellular Component	GO:0043025	neuronal cell body	IDA	J:105896
Cellular Component	GO:0043025	neuronal cell body	IDA	J:105896
Cellular Component	GO:0043025	neuronal cell body	IDA	J:105896
Cellular Component	GO:0043025	neuronal cell body	IDA	J:105896
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0001891	phagocytic cup	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005840	ribosome	IEA	J:60000
Cellular Component	GO:0015935	small ribosomal subunit	IDA	J:333015
Cellular Component	GO:0015935	small ribosomal subunit	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0007369	gastrulation	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:66091
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	ISO	J:164563
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	IGI	J:211328
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0050765	negative regulation of phagocytosis	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	ISO	J:155856
Biological Process	GO:0043473	pigmentation	IMP	J:223207
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Biological Process	GO:0042998	positive regulation of Golgi to plasma membrane protein transport	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0008104	protein localization	ISO	J:66091
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0072344	rescue of stalled ribosome	ISO	J:164563
Biological Process	GO:0072344	rescue of stalled ribosome	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0006412	translation	IMP	J:223207