GO Annotations Graph

• Symbol: Thpo
• Name: thrombopoietin
• ID: MGI:101875

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:72247
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005179	hormone activity	IEA	J:60000
Molecular Function	GO:0005179	hormone activity	IEA	J:72247
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IEA	J:72247
Biological Process	GO:0035855	megakaryocyte development	ISO	J:164563
Biological Process	GO:0030219	megakaryocyte differentiation	ISO	J:164563
Biological Process	GO:0030099	myeloid cell differentiation	IDA	J:82323
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:181770
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:1902035	positive regulation of hematopoietic stem cell proliferation	IBA	J:265628
Biological Process	GO:1902035	positive regulation of hematopoietic stem cell proliferation	ISO	J:186946
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	IDA	J:181770
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:181770
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:181770
Biological Process	GO:0097696	receptor signaling pathway via STAT	ISO	J:164563
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	IDA	J:181770
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	IBA	J:265628