GO Annotations Graph

• Symbol: Ccl8
• Name: C-C motif chemokine ligand 8
• ID: MGI:101878

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	IEA	J:60000
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:194920
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0048245	eosinophil chemotaxis	IBA	J:265628
Biological Process	GO:0006887	exocytosis	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:0044828	negative regulation by host of viral genome replication	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IMP	J:204300
Biological Process	GO:1901741	positive regulation of myoblast fusion	IMP	J:204300