GO Annotations Graph

• Symbol: Pla2g5
• Name: phospholipase A2, group V
• ID: MGI:101899

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	ISO	J:155856
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	IBA	J:265628
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004623	phospholipase A2 activity	IDA	J:178283
Molecular Function	GO:0005543	phospholipid binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:178283
Cellular Component	GO:0009986	cell surface	IDA	J:37112
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0032009	early phagosome	IDA	J:110309
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032010	phagolysosome	IDA	J:110309
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0050482	arachidonic acid secretion	IDA	J:178283
Biological Process	GO:0050482	arachidonic acid secretion	ISO	J:155856
Biological Process	GO:0050482	arachidonic acid secretion	IBA	J:265628
Biological Process	GO:0035965	cardiolipin acyl-chain remodeling	ISO	J:164563
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0019370	leukotriene biosynthetic process	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	ISO	J:155856
Biological Process	GO:0016042	lipid catabolic process	IEA	J:72247
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	IDA	J:285014
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	IMP	J:215319
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:215319
Biological Process	GO:0042130	negative regulation of T cell proliferation	IBA	J:265628
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:0090385	phagosome-lysosome fusion	IMP	J:147503
Biological Process	GO:0034638	phosphatidylcholine catabolic process	ISO	J:164563
Biological Process	GO:0009395	phospholipid catabolic process	IEA	J:60000
Biological Process	GO:0006644	phospholipid metabolic process	IDA	J:178283
Biological Process	GO:0006644	phospholipid metabolic process	IBA	J:265628
Biological Process	GO:0006663	platelet activating factor biosynthetic process	ISO	J:155856
Biological Process	GO:1905036	positive regulation of antifungal innate immune response	IMP	J:147503
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	IMP	J:236850
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	ISO	J:164563
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	IDA	J:285014
Biological Process	GO:1903028	positive regulation of opsonization	IMP	J:147503
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:110309
Biological Process	GO:1905164	positive regulation of phagosome maturation	IMP	J:147503
Biological Process	GO:0010518	positive regulation of phospholipase activity	ISO	J:164563
Biological Process	GO:0043030	regulation of macrophage activation	IMP	J:215319