GO Annotations Graph

• Symbol: Mmp14
• Name: matrix metallopeptidase 14 (membrane-inserted)
• ID: MGI:101900

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070006	metalloaminopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IMP	J:227091
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:173235
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0044354	macropinosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0060348	bone development	IGI	J:130212
Biological Process	GO:0060348	bone development	IGI	J:130212
Biological Process	GO:0060348	bone development	IGI	J:130212
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:95881
Biological Process	GO:0016477	cell migration	IMP	J:95881
Biological Process	GO:0035988	chondrocyte proliferation	IGI	J:130212
Biological Process	GO:0030574	collagen catabolic process	IBA	J:265628
Biological Process	GO:0030574	collagen catabolic process	IGI	J:130212
Biological Process	GO:0097094	craniofacial suture morphogenesis	IGI	J:130212
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:130212
Biological Process	GO:0001958	endochondral ossification	IGI	J:130212
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0060322	head development	IMP	J:223062
Biological Process	GO:0030324	lung development	IMP	J:95881
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IMP	J:173235
Biological Process	GO:0001503	ossification	IGI	J:130212
Biological Process	GO:0045579	positive regulation of B cell differentiation	IMP	J:173235
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:1905523	positive regulation of macrophage migration	IMP	J:227091
Biological Process	GO:0010831	positive regulation of myotube differentiation	IMP	J:173235
Biological Process	GO:0010954	positive regulation of protein processing	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0009725	response to hormone	ISO	J:155856
Biological Process	GO:0001501	skeletal system development	IBA	J:265628
Biological Process	GO:0048771	tissue remodeling	ISO	J:155856
Biological Process	GO:0031638	zymogen activation	ISO	J:164563
Biological Process	GO:0031638	zymogen activation	IBA	J:265628
Biological Process	GO:0031638	zymogen activation	IMP	J:95881