GO Annotations Graph

• Symbol: F2rl1
• Name: F2R like trypsin receptor 1
• ID: MGI:101910

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:164563
Molecular Function	GO:0004930	G protein-coupled receptor activity	IMP	J:175344
Molecular Function	GO:0004930	G protein-coupled receptor activity	IBA	J:265628
Molecular Function	GO:0001965	G-protein alpha-subunit binding	IDA	J:175344
Molecular Function	GO:0031681	G-protein beta-subunit binding	IDA	J:175344
Molecular Function	GO:0032795	heterotrimeric G-protein binding	TAS	J:175344
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:130781
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0001648	proteinase-activated receptor activity	IMP	J:130781
Molecular Function	GO:0015057	thrombin-activated receptor activity	IEA	J:72247
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0031143	pseudopodium	IDA	J:85273
Biological Process	GO:0007596	blood coagulation	IEA	J:72247
Biological Process	GO:0045217	cell-cell junction maintenance	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IDA	J:149290
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IMP	J:130781
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0050900	leukocyte migration	ISO	J:164563
Biological Process	GO:0070661	leukocyte proliferation	IDA	J:149290
Biological Process	GO:0097029	mature conventional dendritic cell differentiation	ISO	J:164563
Biological Process	GO:0097029	mature conventional dendritic cell differentiation	IDA	J:166198
Biological Process	GO:0032682	negative regulation of chemokine production	ISO	J:164563
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:130781
Biological Process	GO:0046329	negative regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	ISO	J:164563
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0042119	neutrophil activation	ISO	J:164563
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IDA	J:175344
Biological Process	GO:0032722	positive regulation of chemokine production	IDA	J:149290
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	IDA	J:85273
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA	J:175344
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	J:265628
Biological Process	GO:0043311	positive regulation of eosinophil degranulation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:175344
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0003104	positive regulation of glomerular filtration	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	ISO	J:164563
Biological Process	GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium	ISO	J:164563
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:175344
Biological Process	GO:0050927	positive regulation of positive chemotaxis	ISO	J:164563
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	IDA	J:85273
Biological Process	GO:1900135	positive regulation of renin secretion into blood stream	IDA	J:182471
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	IDA	J:175344
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0032930	positive regulation of superoxide anion generation	ISO	J:164563
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	ISO	J:164563
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	ISO	J:164563
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:149290
Biological Process	GO:0099109	potassium channel activating, G protein-coupled receptor signaling pathway	IMP	J:130781
Biological Process	GO:0030193	regulation of blood coagulation	ISO	J:164563
Biological Process	GO:2000341	regulation of chemokine (C-X-C motif) ligand 2 production	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0046328	regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0002286	T cell activation involved in immune response	IDA	J:166198
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	IEA	J:72247
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042311	vasodilation	IDA	J:182471
Biological Process	GO:0042311	vasodilation	IMP	J:96312