GO Annotations Graph

• Symbol: Ap2a1
• Name: adaptor-related protein complex 2, alpha 1 subunit
• ID: MGI:101921

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035615	clathrin adaptor activity	IBA	J:265628
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114134
Molecular Function	GO:0005515	protein binding	IPI	J:201438
Molecular Function	GO:0005515	protein binding	IPI	J:119025
Molecular Function	GO:0005515	protein binding	IPI	J:168194
Molecular Function	GO:0019901	protein kinase binding	IPI	J:169453
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0030122	AP-2 adaptor complex	IDA	J:201438
Cellular Component	GO:0030122	AP-2 adaptor complex	ISO	J:164563
Cellular Component	GO:0030122	AP-2 adaptor complex	NAS	J:240303
Cellular Component	GO:0030122	AP-2 adaptor complex	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0030131	clathrin adaptor complex	IEA	J:72247
Cellular Component	GO:0005905	clathrin-coated pit	IEA	J:60000
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:155856
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	NAS	J:320128
Cellular Component	GO:0032433	filopodium tip	IDA	J:204152
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030117	membrane coat	IDA	J:75306
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	TAS	J:48443
Biological Process	GO:0072583	clathrin-dependent endocytosis	IDA	J:201438
Biological Process	GO:0072583	clathrin-dependent endocytosis	ISO	J:164563
Biological Process	GO:0072583	clathrin-dependent endocytosis	NAS	J:320128
Biological Process	GO:0072583	clathrin-dependent endocytosis	IBA	J:265628
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0006886	intracellular protein transport	TAS	J:48443
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	NAS	J:319684
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0015031	protein transport	IEA	J:72247
Biological Process	GO:0016192	vesicle-mediated transport	NAS	J:319992
Biological Process	GO:0016192	vesicle-mediated transport	TAS	J:48443