GO Annotations Graph

• Symbol: Slc12a2
• Name: solute carrier family 12, member 2
• ID: MGI:101924

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0015377	chloride:monoatomic cation symporter activity	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0046873	metal ion transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015079	potassium ion transmembrane transporter activity	IMP	J:284976
Molecular Function	GO:0005515	protein binding	IPI	J:139340
Molecular Function	GO:0005515	protein binding	IPI	J:80982
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	IC	J:284976
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	ISO	J:155856
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	IBA	J:265628
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Molecular Function	GO:0022857	transmembrane transporter activity	IEA	J:72247
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:80982
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:176751
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:80648
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:76874
Cellular Component	GO:0044297	cell body	IDA	J:284976
Cellular Component	GO:0071944	cell periphery	IDA	J:219851
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IDA	J:284976
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	IDA	J:219851
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0072488	ammonium transmembrane transport	ISO	J:164563
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:76974
Biological Process	GO:0006884	cell volume homeostasis	IMP	J:284976
Biological Process	GO:0006884	cell volume homeostasis	IBA	J:265628
Biological Process	GO:1990869	cellular response to chemokine	IMP	J:259583
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:293611
Biological Process	GO:0035865	cellular response to potassium ion	IMP	J:284976
Biological Process	GO:0055064	chloride ion homeostasis	IBA	J:265628
Biological Process	GO:1902476	chloride transmembrane transport	IMP	J:284976
Biological Process	GO:1902476	chloride transmembrane transport	IBA	J:265628
Biological Process	GO:0006821	chloride transport	ISO	J:155856
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:108937
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	ISO	J:155856
Biological Process	GO:0006972	hyperosmotic response	ISO	J:155856
Biological Process	GO:0098658	inorganic anion import across plasma membrane	IMP	J:284976
Biological Process	GO:0098659	inorganic cation import across plasma membrane	ISO	J:164563
Biological Process	GO:0030644	intracellular chloride ion homeostasis	IMP	J:284976
Biological Process	GO:0030007	intracellular potassium ion homeostasis	IMP	J:284976
Biological Process	GO:0006883	intracellular sodium ion homeostasis	IMP	J:284976
Biological Process	GO:0035633	maintenance of blood-brain barrier	IMP	J:284979
Biological Process	GO:0060763	mammary duct terminal end bud growth	IMP	J:76874
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IMP	J:76874
Biological Process	GO:0061044	negative regulation of vascular wound healing	IMP	J:284979
Biological Process	GO:1904450	positive regulation of aspartate secretion	IMP	J:284976
Biological Process	GO:0045795	positive regulation of cell volume	ISO	J:155856
Biological Process	GO:0055075	potassium ion homeostasis	IBA	J:265628
Biological Process	GO:1990573	potassium ion import across plasma membrane	IMP	J:284976
Biological Process	GO:1990573	potassium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0006813	potassium ion transport	ISO	J:155856
Biological Process	GO:1904464	regulation of matrix metallopeptidase secretion	IMP	J:284979
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	IGI	J:219851
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	IMP	J:102876
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	ISO	J:155856
Biological Process	GO:0055078	sodium ion homeostasis	IBA	J:265628
Biological Process	GO:0098719	sodium ion import across plasma membrane	IMP	J:284976
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0010818	T cell chemotaxis	ISO	J:164563
Biological Process	GO:0010818	T cell chemotaxis	IMP	J:259583
Biological Process	GO:0070634	transepithelial ammonium transport	ISO	J:164563
Biological Process	GO:0030321	transepithelial chloride transport	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247