GO Annotations Graph

• Symbol: Cpe
• Name: carboxypeptidase E
• ID: MGI:101932

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004180	carboxypeptidase activity	ISO	J:155856
Molecular Function	GO:0004180	carboxypeptidase activity	IMP	J:24436
Molecular Function	GO:0004180	carboxypeptidase activity	IMP	J:24436
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0050897	cobalt ion binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004181	metallocarboxypeptidase activity	IBA	J:265628
Molecular Function	GO:0004181	metallocarboxypeptidase activity	IMP	J:43857
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:43857
Molecular Function	GO:0042043	neurexin family protein binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	TAS	Reactome:R-MMU-216806
Molecular Function	GO:0005515	protein binding	IPI	J:102191
Molecular Function	GO:0005515	protein binding	IPI	J:102191
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0031045	dense core granule	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:43857
Cellular Component	GO:0030667	secretory granule membrane	ISO	J:155856
Cellular Component	GO:0030667	secretory granule membrane	TAS	Reactome:R-MMU-216806
Cellular Component	GO:0030667	secretory granule membrane	IDA	J:102191
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	ISO	J:164563
Biological Process	GO:0034230	enkephalin processing	ISO	J:155856
Biological Process	GO:0030070	insulin processing	ISO	J:155856
Biological Process	GO:0030070	insulin processing	IMP	J:43857
Biological Process	GO:0030070	insulin processing	IMP	J:24436
Biological Process	GO:2000173	negative regulation of branching morphogenesis of a nerve	ISO	J:155856
Biological Process	GO:0043171	peptide catabolic process	ISO	J:155856
Biological Process	GO:0030072	peptide hormone secretion	IMP	J:102191
Biological Process	GO:0006518	peptide metabolic process	ISO	J:155856
Biological Process	GO:0006518	peptide metabolic process	IBA	J:265628
Biological Process	GO:0072657	protein localization to membrane	ISO	J:164563
Biological Process	GO:0033366	protein localization to secretory granule	IMP	J:102191
Biological Process	GO:0016485	protein processing	ISO	J:155856
Biological Process	GO:0016485	protein processing	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0016055	Wnt signaling pathway	ISO	J:164563