Mlh1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Mlh1
mutL homolog 1
MGI:101938

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	IBA	J:265628
Molecular Function	GO:0140664	ATP-dependent DNA damage sensor activity	IEA	J:72247
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:87869
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0032137	guanine/thymine mispair binding	ISO	J:73065
Molecular Function	GO:0032137	guanine/thymine mispair binding	IGI	J:111285
Molecular Function	GO:0030983	mismatched DNA binding	IEA	J:72247
Molecular Function	GO:0032407	MutSalpha complex binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005712	chiasma	IDA	J:120745
Cellular Component	GO:0005712	chiasma	IDA	J:176168
Cellular Component	GO:0005712	chiasma	IDA	J:270644
Cellular Component	GO:0005712	chiasma	IDA	J:239544
Cellular Component	GO:0005712	chiasma	IDA	J:123677
Cellular Component	GO:0005712	chiasma	IDA	J:284005
Cellular Component	GO:0005694	chromosome	IDA	J:285969
Cellular Component	GO:0005694	chromosome	IDA	J:76360
Cellular Component	GO:0000793	condensed chromosome	IDA	J:85108
Cellular Component	GO:0000793	condensed chromosome	IDA	J:78200
Cellular Component	GO:0000793	condensed chromosome	IMP	J:34291
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:195265
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:215796
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:131722
Cellular Component	GO:0005715	late recombination nodule	IDA	J:236226
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:123677
Cellular Component	GO:0032300	mismatch repair complex	IEA	J:72247
Cellular Component	GO:0032389	MutLalpha complex	IBA	J:265628
Cellular Component	GO:0032389	MutLalpha complex	IDA	J:111285
Cellular Component	GO:0032389	MutLalpha complex	IDA	J:182264
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0000795	synaptonemal complex	IDA	J:93127
Cellular Component	GO:0000795	synaptonemal complex	IDA	J:104493
Cellular Component	GO:0000795	synaptonemal complex	ISS	J:113188
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IMP	J:86055
Biological Process	GO:0006974	DNA damage response	IGI	J:60616
Biological Process	GO:0006974	DNA damage response	IGI	J:47642
Biological Process	GO:0006974	DNA damage response	IMP	J:102704
Biological Process	GO:0006281	DNA repair	IMP	J:94712
Biological Process	GO:0006281	DNA repair	IMP	J:85814
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:89325
Biological Process	GO:0016321	female meiosis chromosome segregation	IMP	J:216866
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IMP	J:33878
Biological Process	GO:0045143	homologous chromosome segregation	IMP	J:216866
Biological Process	GO:0045143	homologous chromosome segregation	IMP	J:216866
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:86055
Biological Process	GO:0045190	isotype switching	IMP	J:83489
Biological Process	GO:0000237	leptotene	IMP	J:147391
Biological Process	GO:0007060	male meiosis chromosome segregation	IMP	J:216866
Biological Process	GO:0007140	male meiotic nuclear division	IMP	J:93127
Biological Process	GO:0051321	meiotic cell cycle	IDA	J:78200
Biological Process	GO:0051321	meiotic cell cycle	TAS	J:62204
Biological Process	GO:0045132	meiotic chromosome segregation	IMP	J:78790
Biological Process	GO:0043060	meiotic metaphase I plate congression	IMP	J:56169
Biological Process	GO:0051257	meiotic spindle midzone assembly	IMP	J:56169
Biological Process	GO:0045141	meiotic telomere clustering	IMP	J:147391
Biological Process	GO:0006298	mismatch repair	IBA	J:265628
Biological Process	GO:0006298	mismatch repair	IMP	J:53451
Biological Process	GO:0006298	mismatch repair	IMP	J:47642
Biological Process	GO:0006298	mismatch repair	IMP	J:33878
Biological Process	GO:0006298	mismatch repair	IMP	J:62824
Biological Process	GO:0006298	mismatch repair	IMP	J:115827
Biological Process	GO:0006298	mismatch repair	IMP	J:102704
Biological Process	GO:0006298	mismatch repair	IDA	J:61445
Biological Process	GO:0006298	mismatch repair	IMP	J:68922
Biological Process	GO:0006298	mismatch repair	IMP	J:55724
Biological Process	GO:0006298	mismatch repair	ISO	J:71822
Biological Process	GO:0006298	mismatch repair	IMP	J:60616
Biological Process	GO:0006298	mismatch repair	IMP	J:115296
Biological Process	GO:0006298	mismatch repair	ISO	J:198961
Biological Process	GO:0006298	mismatch repair	IMP	J:46382
Biological Process	GO:0045950	negative regulation of mitotic recombination	IMP	J:94712
Biological Process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	IMP	J:69102
Biological Process	GO:0048477	oogenesis	IMP	J:33878
Biological Process	GO:0048298	positive regulation of isotype switching to IgA isotypes	IMP	J:56764
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP	J:56764
Biological Process	GO:0007131	reciprocal meiotic recombination	IMP	J:56169
Biological Process	GO:0007131	reciprocal meiotic recombination	IMP	J:104590
Biological Process	GO:0007131	reciprocal meiotic recombination	IMP	J:34291
Biological Process	GO:0000712	resolution of meiotic recombination intermediates	IMP	J:78790
Biological Process	GO:0000712	resolution of meiotic recombination intermediates	IMP	J:56169
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IBA	J:265628
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:53460
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:115296
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:124827
Biological Process	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	IGI	J:83489
Biological Process	GO:0007283	spermatogenesis	IMP	J:33878
Biological Process	GO:0007283	spermatogenesis	IMP	J:78790

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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