GO Annotations Graph

• Symbol: E2f1
• Name: E2F transcription factor 1
• ID: MGI:101941

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:91050
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:65993
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:61792
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:87848
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:99083
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:115574
Molecular Function	GO:0005515	protein binding	IPI	J:113789
Molecular Function	GO:0005515	protein binding	IPI	J:87556
Molecular Function	GO:0005515	protein binding	IPI	J:87556
Molecular Function	GO:0005515	protein binding	IPI	J:79877
Molecular Function	GO:0005515	protein binding	IPI	J:95187
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:72330
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:204913
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:76061
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:36872
Cellular Component	GO:0000228	nuclear chromosome	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8963630
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8979012
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625589
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:36872
Cellular Component	GO:0005634	nucleus	IDA	J:53930
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0035189	Rb-E2F complex	ISO	J:164563
Cellular Component	GO:0035189	Rb-E2F complex	IBA	J:265628
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:53930
Biological Process	GO:0043276	anoikis	IDA	J:87848
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:155856
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:210952
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:72330
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:99083
Biological Process	GO:0030900	forebrain development	IMP	J:96577
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IDA	J:65993
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:1990086	lens fiber cell apoptotic process	IDA	J:65993
Biological Process	GO:0048255	mRNA stabilization	ISO	J:164563
Biological Process	GO:0043392	negative regulation of DNA binding	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:72330
Biological Process	GO:0070345	negative regulation of fat cell proliferation	IMP	J:161707
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:92455
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:99083
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:86128
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:63626
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:26103
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:204913
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:79877
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:65993
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:99083
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:87848
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:87556
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:65792
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	ISO	J:164563