GO Annotations Graph

• Symbol: Phb2
• Name: prohibitin 2
• ID: MGI:102520

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0033218	amide binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114106
Molecular Function	GO:0005515	protein binding	IPI	J:273588
Molecular Function	GO:0005515	protein binding	IPI	J:273588
Molecular Function	GO:0005515	protein binding	IPI	J:113940
Molecular Function	GO:0005515	protein binding	IPI	J:215238
Molecular Function	GO:0005515	protein binding	IPI	J:191189
Molecular Function	GO:0005515	protein binding	IPI	J:129069
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0046625	sphingolipid binding	IDA	J:273588
Molecular Function	GO:0046625	sphingolipid binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:219621
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098800	inner mitochondrial membrane protein complex	IDA	J:215238
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:273588
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:114058
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0035632	mitochondrial prohibitin complex	ISO	J:164563
Cellular Component	GO:0035632	mitochondrial prohibitin complex	IPI	J:273588
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:86816
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:114106
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:273588
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0007202	activation of phospholipase C activity	IDA	J:191189
Biological Process	GO:1990051	activation of protein kinase C activity	IDA	J:191189
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0042113	B cell activation	IDA	J:191189
Biological Process	GO:0023035	CD40 signaling pathway	IDA	J:191189
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	IMP	J:117151
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:117151
Biological Process	GO:0060744	mammary gland branching involved in thelarche	IMP	J:117151
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:117151
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:117151
Biological Process	GO:0007005	mitochondrion organization	NAS	J:136807
Biological Process	GO:0007005	mitochondrion organization	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	IBA	J:265628
Biological Process	GO:0000423	mitophagy	ISO	J:164563
Biological Process	GO:0000423	mitophagy	IDA	J:289072
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:114106
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	IMP	J:117151
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	IGI	J:129069
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	IMP	J:117151
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0031536	positive regulation of exit from mitosis	ISO	J:164563
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IDA	J:191189
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	J:191189
Biological Process	GO:0006606	protein import into nucleus	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	IMP	J:117151
Biological Process	GO:1900208	regulation of cardiolipin metabolic process	IMP	J:215238
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	IMP	J:273588
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	ISO	J:164563
Biological Process	GO:0039529	RIG-I signaling pathway	ISO	J:164563
Biological Process	GO:0007062	sister chromatid cohesion	ISO	J:164563