Tsc2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tsc2
TSC complex subunit 2
MGI:102548

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	IDA	J:131386
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:155856
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:200369
Molecular Function	GO:0005515	protein binding	IPI	J:139563
Molecular Function	GO:0005515	protein binding	IPI	J:73510
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:73510
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:72247
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:164563
Cellular Component	GO:0045202	synapse	EXP	J:263419
Cellular Component	GO:0045202	synapse	IDA	J:263419
Cellular Component	GO:0045202	synapse	EXP	J:263376
Cellular Component	GO:0045202	synapse	IDA	J:263376
Cellular Component	GO:0033596	TSC1-TSC2 complex	ISO	J:164563
Cellular Component	GO:0033596	TSC1-TSC2 complex	IBA	J:265628
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0043276	anoikis	ISO	J:164563
Biological Process	GO:0043276	anoikis	IMP	J:238448
Biological Process	GO:0042100	B cell proliferation	IGI	J:100095
Biological Process	GO:0008283	cell population proliferation	IMP	J:52464
Biological Process	GO:0008283	cell population proliferation	IMP	J:57631
Biological Process	GO:0008283	cell population proliferation	IMP	J:57631
Biological Process	GO:0008283	cell population proliferation	IMP	J:52464
Biological Process	GO:0008283	cell population proliferation	IGI	J:100094
Biological Process	GO:0008283	cell population proliferation	IMP	J:57631
Biological Process	GO:0008283	cell population proliferation	IGI	J:100095
Biological Process	GO:0030030	cell projection organization	ISO	J:103933
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:136406
Biological Process	GO:0030010	establishment of cell polarity	ISO	J:155856
Biological Process	GO:0045184	establishment of protein localization	ISO	J:155856
Biological Process	GO:0098976	excitatory chemical synaptic transmission	IMP	J:271893
Biological Process	GO:0046323	glucose import	IMP	J:136406
Biological Process	GO:0007507	heart development	IMP	J:52464
Biological Process	GO:0098977	inhibitory chemical synaptic transmission	IMP	J:271893
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:91846
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:91846
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:91846
Biological Process	GO:0050771	negative regulation of axonogenesis	ISO	J:155856
Biological Process	GO:0030889	negative regulation of B cell proliferation	IGI	J:100095
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:52464
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:57631
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:100094
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:62413
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:103933
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:155856
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:155856
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IMP	J:100095
Biological Process	GO:0048550	negative regulation of pinocytosis	ISO	J:155856
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:91846
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:91846
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IGI	J:100095
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:100095
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0042130	negative regulation of T cell proliferation	IGI	J:100095
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032007	negative regulation of TOR signaling	IGI	J:238448
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:155856
Biological Process	GO:0032007	negative regulation of TOR signaling	IBA	J:265628
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:131386
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IMP	J:200700
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0001843	neural tube closure	IMP	J:52464
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:100095
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:91846
Biological Process	GO:0050918	positive chemotaxis	IMP	J:91846
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:200700
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	IEA	J:72247
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:238448
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:161320
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:204748
Biological Process	GO:0006606	protein import into nucleus	IMP	J:62413
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:100095
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:100095
Biological Process	GO:0008104	protein localization	IDA	J:73510
Biological Process	GO:0034394	protein localization to cell surface	ISO	J:155856
Biological Process	GO:0044861	protein transport into plasma membrane raft	IMP	J:136406
Biological Process	GO:0051726	regulation of cell cycle	IBA	J:265628
Biological Process	GO:0030100	regulation of endocytosis	IMP	J:62413
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IMP	J:79972
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0001666	response to hypoxia	IMP	J:131386
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0042098	T cell proliferation	IGI	J:100095
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:204748

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24