Tsc2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tsc2
TSC complex subunit 2
MGI:102548

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	IDA	J:131386
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:155856
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:200369
Molecular Function	GO:0005515	protein binding	IPI	J:139563
Molecular Function	GO:0005515	protein binding	IPI	J:73510
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:73510
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IEA	J:72247
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:164563
Cellular Component	GO:0045202	synapse	EXP	J:263419
Cellular Component	GO:0045202	synapse	IDA	J:263419
Cellular Component	GO:0045202	synapse	EXP	J:263376
Cellular Component	GO:0045202	synapse	IDA	J:263376
Cellular Component	GO:0033596	TSC1-TSC2 complex	ISO	J:164563
Cellular Component	GO:0033596	TSC1-TSC2 complex	IBA	J:265628
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0043276	anoikis	ISO	J:164563
Biological Process	GO:0043276	anoikis	IMP	J:238448
Biological Process	GO:0042100	B cell proliferation	IGI	J:100095
Biological Process	GO:0008283	cell population proliferation	IMP	J:52464
Biological Process	GO:0008283	cell population proliferation	IMP	J:57631
Biological Process	GO:0008283	cell population proliferation	IMP	J:57631
Biological Process	GO:0008283	cell population proliferation	IMP	J:52464
Biological Process	GO:0008283	cell population proliferation	IGI	J:100094
Biological Process	GO:0008283	cell population proliferation	IMP	J:57631
Biological Process	GO:0008283	cell population proliferation	IGI	J:100095
Biological Process	GO:0030030	cell projection organization	ISO	J:103933
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:136406
Biological Process	GO:0030010	establishment of cell polarity	ISO	J:155856
Biological Process	GO:0045184	establishment of protein localization	ISO	J:155856
Biological Process	GO:0098976	excitatory chemical synaptic transmission	IMP	J:271893
Biological Process	GO:0046323	glucose import	IMP	J:136406
Biological Process	GO:0007507	heart development	IMP	J:52464
Biological Process	GO:0098977	inhibitory chemical synaptic transmission	IMP	J:271893
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:91846
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:91846
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:91846
Biological Process	GO:0050771	negative regulation of axonogenesis	ISO	J:155856
Biological Process	GO:0030889	negative regulation of B cell proliferation	IGI	J:100095
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:52464
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:57631
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:100094
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:62413
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:103933
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:155856
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0016242	negative regulation of macroautophagy	ISO	J:155856
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IMP	J:100095
Biological Process	GO:0048550	negative regulation of pinocytosis	ISO	J:155856
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:91846
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:91846
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IGI	J:100095
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:100095
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0042130	negative regulation of T cell proliferation	IGI	J:100095
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032007	negative regulation of TOR signaling	IGI	J:238448
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:155856
Biological Process	GO:0032007	negative regulation of TOR signaling	IBA	J:265628
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:131386
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IMP	J:200700
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0001843	neural tube closure	IMP	J:52464
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:100095
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP	J:91846
Biological Process	GO:0050918	positive chemotaxis	IMP	J:91846
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:200700
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	IEA	J:72247
Biological Process	GO:0016239	positive regulation of macroautophagy	ISO	J:164563
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:238448
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:161320
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:204748
Biological Process	GO:0006606	protein import into nucleus	IMP	J:62413
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:100095
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:100095
Biological Process	GO:0008104	protein localization	IDA	J:73510
Biological Process	GO:0034394	protein localization to cell surface	ISO	J:155856
Biological Process	GO:0044861	protein transport into plasma membrane raft	IMP	J:136406
Biological Process	GO:0051726	regulation of cell cycle	IBA	J:265628
Biological Process	GO:0030100	regulation of endocytosis	IMP	J:62413
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IMP	J:79972
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0001666	response to hypoxia	IMP	J:131386
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0042098	T cell proliferation	IGI	J:100095
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:204748

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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