GO Annotations Graph

• Symbol: Runx3
• Name: runt related transcription factor 3
• ID: MGI:102672

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IDA	J:85208
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:125598
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:125746
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:125746
Molecular Function	GO:0005515	protein binding	IPI	J:167439
Molecular Function	GO:0005515	protein binding	IPI	J:160369
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:125598
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:125598
Cellular Component	GO:0016513	core-binding factor complex	TAS	J:131081
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8949284
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:93240
Biological Process	GO:0007411	axon guidance	IMP	J:79268
Biological Process	GO:0007411	axon guidance	IMP	J:79268
Biological Process	GO:0048469	cell maturation	IGI	J:89327
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:191689
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:99572
Biological Process	GO:0030097	hemopoiesis	IBA	J:265628
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	IMP	J:131081
Biological Process	GO:0045786	negative regulation of cell cycle	IMP	J:75869
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:75869
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:125598
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:131081
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0031175	neuron projection development	IMP	J:79268
Biological Process	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	IMP	J:131081
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IMP	J:75869
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0045595	regulation of cell differentiation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0071559	response to transforming growth factor beta	ISO	J:164563
Biological Process	GO:0032609	type II interferon production	IDA	J:160369