Six1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Six1
sine oculis-related homeobox 1
MGI:102780

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IGI	J:147237
Molecular Function	GO:0003682	chromatin binding	IGI	J:147237
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:103002
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:124751
Molecular Function	GO:0005515	protein binding	IPI	J:147237
Molecular Function	GO:0005515	protein binding	IPI	J:90664
Molecular Function	GO:0005515	protein binding	IPI	J:212814
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0005515	protein binding	IPI	J:157941
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:51236
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:51236
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:119948
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:86619
Cellular Component	GO:0005634	nucleus	IDA	J:51236
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:86619
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:147237
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:147237
Biological Process	GO:0048856	anatomical structure development	IGI	J:108725
Biological Process	GO:0048856	anatomical structure development	IGI	J:108725
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IGI	J:83432
Biological Process	GO:1905243	cellular response to 3,3',5-triiodo-L-thyronine	ISO	J:155856
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:84974
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:163483
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IGI	J:98519
Biological Process	GO:0086100	endothelin receptor signaling pathway	IMP	J:241567
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:108725
Biological Process	GO:0021610	facial nerve morphogenesis	IMP	J:84974
Biological Process	GO:0061197	fungiform papilla morphogenesis	IMP	J:190431
Biological Process	GO:0010467	gene expression	IMP	J:241567
Biological Process	GO:0048699	generation of neurons	IMP	J:114468
Biological Process	GO:0048839	inner ear development	IMP	J:149467
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:98519
Biological Process	GO:0001822	kidney development	IMP	J:119570
Biological Process	GO:0072198	mesenchymal cell proliferation involved in ureter development	IGI	J:157941
Biological Process	GO:0072198	mesenchymal cell proliferation involved in ureter development	IGI	J:157941
Biological Process	GO:0072172	mesonephric tubule formation	IMP	J:172983
Biological Process	GO:0072075	metanephric mesenchyme development	IMP	J:172983
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:84974
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0051451	myoblast migration	IGI	J:98519
Biological Process	GO:0051451	myoblast migration	IGI	J:98519
Biological Process	GO:0051450	myoblast proliferation	IGI	J:157941
Biological Process	GO:0061055	myotome development	IMP	J:98519
Biological Process	GO:0061055	myotome development	IMP	J:156719
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:98519
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:145187
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:114468
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:171473
Biological Process	GO:0014033	neural crest cell differentiation	IGI	J:241567
Biological Process	GO:0022008	neurogenesis	IMP	J:145187
Biological Process	GO:0048665	neuron fate specification	IGI	J:184001
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:241567
Biological Process	GO:0030910	olfactory placode formation	IMP	J:145187
Biological Process	GO:0001759	organ induction	IMP	J:83432
Biological Process	GO:0071599	otic vesicle development	IMP	J:119574
Biological Process	GO:0071599	otic vesicle development	IGI	J:184001
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0007389	pattern specification process	IMP	J:119574
Biological Process	GO:0007389	pattern specification process	IGI	J:108725
Biological Process	GO:0060037	pharyngeal system development	IMP	J:108725
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:172983
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IGI	J:171473
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	IMP	J:237490
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:122815
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:172983
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:165033
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:156719
Biological Process	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	IGI	J:157941
Biological Process	GO:2000288	positive regulation of myoblast proliferation	IGI	J:157941
Biological Process	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	IGI	J:172023
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:184001
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:184001
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:172023
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:103002
Biological Process	GO:0072107	positive regulation of ureteric bud formation	IMP	J:172983
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0072095	regulation of branch elongation involved in ureteric bud branching	IMP	J:172983
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:86619
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:145187
Biological Process	GO:0010468	regulation of gene expression	IGI	J:178379
Biological Process	GO:0045664	regulation of neuron differentiation	IMP	J:94396
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0032880	regulation of protein localization	IGI	J:178379
Biological Process	GO:2001014	regulation of skeletal muscle cell differentiation	IDA	J:165033
Biological Process	GO:0014857	regulation of skeletal muscle cell proliferation	IBA	J:265628
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	IDA	J:165033
Biological Process	GO:0008582	regulation of synaptic assembly at neuromuscular junction	IGI	J:178379
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	IMP	J:84974
Biological Process	GO:0048741	skeletal muscle fiber development	IBA	J:265628
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:122815
Biological Process	GO:0007519	skeletal muscle tissue development	IGI	J:98519
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:84974
Biological Process	GO:0007382	specification of segmental identity, maxillary segment	IMP	J:241567
Biological Process	GO:0048538	thymus development	IMP	J:108725
Biological Process	GO:0048538	thymus development	IGI	J:108725
Biological Process	GO:0030878	thyroid gland development	IMP	J:108725
Biological Process	GO:0043586	tongue development	IMP	J:190431
Biological Process	GO:0061551	trigeminal ganglion development	IMP	J:114468
Biological Process	GO:0072193	ureter smooth muscle cell differentiation	IMP	J:157941
Biological Process	GO:0001657	ureteric bud development	IGI	J:100569
Biological Process	GO:0001657	ureteric bud development	IGI	J:100569
Biological Process	GO:0001657	ureteric bud development	IMP	J:83432

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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