Acvr2a GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Acvr2a
activin receptor IIA
MGI:102806

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0048185	activin binding	ISO	J:155856
Molecular Function	GO:0048185	activin binding	IBA	J:265628
Molecular Function	GO:0048185	activin binding	IPI	J:11226
Molecular Function	GO:0017002	activin receptor activity	ISO	J:164563
Molecular Function	GO:0017002	activin receptor activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0098821	BMP receptor activity	ISO	J:164563
Molecular Function	GO:0098821	BMP receptor activity	IMP	J:229306
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IMP	J:79880
Molecular Function	GO:0019838	growth factor binding	IPI	J:70668
Molecular Function	GO:0034711	inhibin binding	IPI	J:116370
Molecular Function	GO:0034711	inhibin binding	ISO	J:155856
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	IPI	J:108339
Molecular Function	GO:0005515	protein binding	IPI	J:108339
Molecular Function	GO:0005515	protein binding	IPI	J:108339
Molecular Function	GO:0005515	protein binding	IPI	J:245705
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0043621	protein self-association	IPI	J:32794
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-2470487
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Cellular Component	GO:0048179	activin receptor complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:108339
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0034673	inhibin-betaglycan-ActRII complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1225898
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2470487
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2470495
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:114533
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:57262
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:114533
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:229306
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:123381
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:123381
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0007368	determination of left/right symmetry	IGI	J:114533
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:23924
Biological Process	GO:0001702	gastrulation with mouth forming second	IGI	J:57262
Biological Process	GO:0008584	male gonad development	IMP	J:23924
Biological Process	GO:0007498	mesoderm development	IGI	J:57262
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:104362
Biological Process	GO:0043084	penile erection	IMP	J:115447
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	ISO	J:155856
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:123381
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IMP	J:115447
Biological Process	GO:0009966	regulation of signal transduction	IDA	J:127541
Biological Process	GO:0060011	Sertoli cell proliferation	IMP	J:71932
Biological Process	GO:0042713	sperm ejaculation	IMP	J:115447
Biological Process	GO:0007283	spermatogenesis	IGI	J:108808
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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