GO Annotations Graph

• Symbol: Pdx1
• Name: pancreatic and duodenal homeobox 1
• ID: MGI:102851

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:153774
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:105459
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:171241
Molecular Function	GO:0005515	protein binding	IPI	J:201256
Molecular Function	GO:0005515	protein binding	IPI	J:117676
Molecular Function	GO:0005515	protein binding	IPI	J:89879
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:210927
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:105459
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:117676
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:80902
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:85764
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:88815
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186507
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-186550
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:105207
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:120581
Cellular Component	GO:0016607	nuclear speck	IDA	J:89879
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-190088
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:130389
Cellular Component	GO:0005634	nucleus	IDA	J:127471
Cellular Component	GO:0005634	nucleus	IDA	J:87397
Cellular Component	GO:0005634	nucleus	IDA	J:87397
Cellular Component	GO:0005634	nucleus	IDA	J:125466
Cellular Component	GO:0005634	nucleus	IDA	J:80826
Cellular Component	GO:0005634	nucleus	IDA	J:105459
Cellular Component	GO:0005634	nucleus	IDA	J:99302
Cellular Component	GO:0005634	nucleus	IDA	J:87397
Biological Process	GO:0030154	cell differentiation	ISO	J:155856
Biological Process	GO:0008283	cell population proliferation	IMP	J:130389
Biological Process	GO:0008283	cell population proliferation	IMP	J:130389
Biological Process	GO:0051594	detection of glucose	ISO	J:155856
Biological Process	GO:0048565	digestive tract development	IMP	J:151981
Biological Process	GO:0006351	DNA-templated transcription	ISO	J:155856
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:130389
Biological Process	GO:0035883	enteroendocrine cell differentiation	IMP	J:104617
Biological Process	GO:0035883	enteroendocrine cell differentiation	IMP	J:104617
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:130389
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:103522
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:103522
Biological Process	GO:0031017	exocrine pancreas development	IMP	J:103522
Biological Process	GO:0042593	glucose homeostasis	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	IMP	J:130389
Biological Process	GO:0042593	glucose homeostasis	IGI	J:165268
Biological Process	GO:0006006	glucose metabolic process	IDA	J:84857
Biological Process	GO:0030073	insulin secretion	ISO	J:164563
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:165268
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:165268
Biological Process	GO:0001889	liver development	IMP	J:151981
Biological Process	GO:0016331	morphogenesis of embryonic epithelium	IMP	J:33133
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:130389
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:165268
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:130389
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117676
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	IMP	J:165268
Biological Process	GO:0007263	nitric oxide mediated signal transduction	ISO	J:164563
Biological Process	GO:0031016	pancreas development	IMP	J:104617
Biological Process	GO:0031016	pancreas development	IMP	J:33133
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0043388	positive regulation of DNA binding	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:80902
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:79560
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:181489
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:211245
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:105459
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:88815
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	IMP	J:130389
Biological Process	GO:0042127	regulation of cell population proliferation	IDA	J:80826
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:88815
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:85764
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0007224	smoothened signaling pathway	ISO	J:155856
Biological Process	GO:0048863	stem cell differentiation	ISO	J:155856
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	IMP	J:165268
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	IMP	J:165268
Biological Process	GO:0003309	type B pancreatic cell differentiation	ISO	J:155856
Biological Process	GO:0003309	type B pancreatic cell differentiation	ISO	J:164563
Biological Process	GO:0003309	type B pancreatic cell differentiation	IBA	J:265628
Biological Process	GO:0003309	type B pancreatic cell differentiation	IMP	J:104617
Biological Process	GO:0044342	type B pancreatic cell proliferation	IMP	J:130389