Cacna1c GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
MGI:103013

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:175643
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:263460
Molecular Function	GO:0005515	protein binding	IPI	J:109447
Molecular Function	GO:0005515	protein binding	IPI	J:163320
Molecular Function	GO:0005515	protein binding	IPI	J:105342
Molecular Function	GO:0005515	protein binding	IPI	J:110984
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0031369	translation initiation factor binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:28645
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:102188
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:3159
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:102383
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:94556
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:84919
Molecular Function	GO:0005245	voltage-gated calcium channel activity	TAS	J:72636
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:112881
Molecular Function	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential	ISO	J:164563
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO	J:164563
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO	J:164563
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	IDA	J:286588
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP	J:238539
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0002095	caveolar macromolecular signaling complex	IDA	J:109447
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043198	dendritic shaft	IDA	J:98871
Cellular Component	GO:0043198	dendritic shaft	IDA	J:98871
Cellular Component	GO:0043198	dendritic shaft	IDA	J:98871
Cellular Component	GO:0043198	dendritic shaft	IDA	J:98871
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	ISO	J:155856
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:118456
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:98871
Cellular Component	GO:0043025	neuronal cell body	IDA	J:98871
Cellular Component	GO:0043025	neuronal cell body	IDA	J:98871
Cellular Component	GO:0043025	neuronal cell body	IDA	J:98871
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-525831
Cellular Component	GO:0005886	plasma membrane	IDA	J:98871
Cellular Component	GO:0005886	plasma membrane	IDA	J:26511
Cellular Component	GO:0005886	plasma membrane	IDA	J:98871
Cellular Component	GO:0005886	plasma membrane	IDA	J:98871
Cellular Component	GO:0005886	plasma membrane	IDA	J:98871
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:164563
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:182140
Cellular Component	GO:0030315	T-tubule	TAS	J:72636
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IBA	J:265628
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IMP	J:327476
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IMP	J:84919
Cellular Component	GO:0005891	voltage-gated calcium channel complex	TAS	J:76458
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:149895
Biological Process	GO:0007628	adult walking behavior	IGI	J:52508
Biological Process	GO:0070509	calcium ion import	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0098703	calcium ion import across plasma membrane	IDA	J:286588
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	IMP	J:118456
Biological Process	GO:0006816	calcium ion transport	IDA	J:28645
Biological Process	GO:0006816	calcium ion transport	IMP	J:102188
Biological Process	GO:0017156	calcium-ion regulated exocytosis	IMP	J:84919
Biological Process	GO:0043010	camera-type eye development	ISO	J:164563
Biological Process	GO:0061337	cardiac conduction	ISO	J:164563
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0086065	cell communication involved in cardiac conduction	IDA	J:286588
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:102188
Biological Process	GO:0035115	embryonic forelimb morphogenesis	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:118456
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:84919
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:286588
Biological Process	GO:0006887	exocytosis	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	IMP	J:84919
Biological Process	GO:0030252	growth hormone secretion	IDA	J:3159
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0002520	immune system development	ISO	J:164563
Biological Process	GO:0030073	insulin secretion	IMP	J:84919
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:118456
Biological Process	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	ISO	J:164563
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	IDA	J:266464
Biological Process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:1904181	positive regulation of membrane depolarization	ISO	J:155856
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:112881
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0046620	regulation of organ growth	IMP	J:118456
Biological Process	GO:0019229	regulation of vasoconstriction	IMP	J:112881
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0006939	smooth muscle contraction	IMP	J:111375
Biological Process	GO:0060083	smooth muscle contraction involved in micturition	IMP	J:118456
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0008542	visual learning	IMP	J:102188

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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