GO Annotations Graph

• Symbol: Il15
• Name: interleukin 15
• ID: MGI:103014

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IMP	J:60915
Molecular Function	GO:0005125	cytokine activity	IDA	J:119213
Molecular Function	GO:0005126	cytokine receptor binding	IEA	J:72247
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:73394
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8983294
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8983313
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8983356
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9007126
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9007137
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-9009867
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0048469	cell maturation	IGI	J:119985
Biological Process	GO:0045062	extrathymic T cell selection	IMP	J:60915
Biological Process	GO:0030212	hyaluronan metabolic process	ISO	J:155856
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048535	lymph node development	IMP	J:60915
Biological Process	GO:0030225	macrophage differentiation	ISO	J:164563
Biological Process	GO:0001779	natural killer cell differentiation	IDA	J:119213
Biological Process	GO:0001779	natural killer cell differentiation	IMP	J:119213
Biological Process	GO:0001787	natural killer cell proliferation	IDA	J:119213
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:256498
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0042119	neutrophil activation	ISO	J:164563
Biological Process	GO:0042119	neutrophil activation	IBA	J:265628
Biological Process	GO:0001866	NK T cell proliferation	IMP	J:60915
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0001819	positive regulation of cytokine production	IBA	J:265628
Biological Process	GO:0050778	positive regulation of immune response	IBA	J:265628
Biological Process	GO:0050778	positive regulation of immune response	IMP	J:60915
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	IGI	J:119985
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	IDA	J:119213
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	IMP	J:119213
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	IDA	J:119213
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:1904100	positive regulation of protein O-linked glycosylation	IMP	J:209421
Biological Process	GO:0042102	positive regulation of T cell proliferation	IBA	J:265628
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:60915
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0050691	regulation of defense response to virus by host	IMP	J:60915
Biological Process	GO:0045580	regulation of T cell differentiation	IMP	J:60915
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	ISO	J:164563