GO Annotations Graph

• Symbol: Stat6
• Name: signal transducer and activator of transcription 6
• ID: MGI:103034

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:107585
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:184505
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:57856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:98563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:90824
Cellular Component	GO:0005737	cytoplasm	IDA	J:82697
Cellular Component	GO:0005737	cytoplasm	IDA	J:77505
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:77505
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:1902170	cellular response to reactive nitrogen species	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0010467	gene expression	IMP	J:298397
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	IMP	J:197516
Biological Process	GO:0048289	isotype switching to IgE isotypes	IGI	J:57856
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:184505
Biological Process	GO:0060443	mammary gland morphogenesis	IMP	J:184505
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:143168
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:165919
Biological Process	GO:0002829	negative regulation of type 2 immune response	IGI	J:56751
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:214452
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	IGI	J:57856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:168252
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:39815
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0070666	regulation of mast cell proliferation	IDA	J:77505
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034097	response to cytokine	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IMP	J:123631
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	IGI	J:165738