GO Annotations Graph

• Symbol: Stat5a
• Name: signal transducer and activator of transcription 5A
• ID: MGI:103036

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:120010
Molecular Function	GO:0003677	DNA binding	IDA	J:98326
Molecular Function	GO:0003677	DNA binding	IDA	J:78881
Molecular Function	GO:0003677	DNA binding	IDA	J:120010
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:239212
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:239212
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0042301	phosphate ion binding	IDA	J:34907
Molecular Function	GO:0005515	protein binding	IPI	J:200410
Molecular Function	GO:0005515	protein binding	IPI	J:34907
Molecular Function	GO:0005515	protein binding	IPI	J:158376
Molecular Function	GO:0005515	protein binding	IPI	J:158376
Molecular Function	GO:0005515	protein binding	IPI	J:78713
Molecular Function	GO:0005515	protein binding	IPI	J:68671
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:151963
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:239212
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:85994
Cellular Component	GO:0005737	cytoplasm	IDA	J:68671
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1168910
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1168923
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-210643
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-210644
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671831
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671832
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671843
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730593
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730596
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012652
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012653
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9012656
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645128
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645136
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676907
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676912
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-210637
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-210643
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2730596
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8865688
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9676907
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9705459
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9705472
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:80648
Biological Process	GO:0050798	activated T cell proliferation	IDA	J:53400
Biological Process	GO:0050798	activated T cell proliferation	IGI	J:98326
Biological Process	GO:0050798	activated T cell proliferation	IGI	J:53400
Biological Process	GO:0030183	B cell differentiation	IGI	J:64603
Biological Process	GO:0008283	cell population proliferation	IGI	J:98325
Biological Process	GO:0008283	cell population proliferation	IDA	J:98325
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:150450
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA	J:204786
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:150450
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:98326
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0046543	development of secondary female sexual characteristics	IMP	J:77412
Biological Process	GO:0046544	development of secondary male sexual characteristics	IMP	J:77412
Biological Process	GO:0046544	development of secondary male sexual characteristics	IGI	J:77412
Biological Process	GO:0030222	eosinophil differentiation	ISO	J:164563
Biological Process	GO:0060742	epithelial cell differentiation involved in prostate gland development	IMP	J:63495
Biological Process	GO:0030218	erythrocyte differentiation	IGI	J:53400
Biological Process	GO:0007565	female pregnancy	IGI	J:95560
Biological Process	GO:0042492	gamma-delta T cell differentiation	IGI	J:92679
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	IDA	J:34907
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0032623	interleukin-2 production	IGI	J:53400
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038156	interleukin-3-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038043	interleukin-5-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007595	lactation	IMP	J:72801
Biological Process	GO:0007595	lactation	IMP	J:77412
Biological Process	GO:0019915	lipid storage	IGI	J:77412
Biological Process	GO:0001553	luteinization	IGI	J:77412
Biological Process	GO:0030098	lymphocyte differentiation	IGI	J:92679
Biological Process	GO:0030879	mammary gland development	IMP	J:77412
Biological Process	GO:0061180	mammary gland epithelium development	IGI	J:76874
Biological Process	GO:0061180	mammary gland epithelium development	IMP	J:76874
Biological Process	GO:0060056	mammary gland involution	ISO	J:155856
Biological Process	GO:0033024	mast cell apoptotic process	IMP	J:101855
Biological Process	GO:0060374	mast cell differentiation	IMP	J:101855
Biological Process	GO:0070662	mast cell proliferation	IMP	J:101855
Biological Process	GO:0000278	mitotic cell cycle	IGI	J:53400
Biological Process	GO:0033028	myeloid cell apoptotic process	IGI	J:98325
Biological Process	GO:0001779	natural killer cell differentiation	IGI	J:53400
Biological Process	GO:0001779	natural killer cell differentiation	IMP	J:112035
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IMP	J:112035
Biological Process	GO:0045647	negative regulation of erythrocyte differentiation	IGI	J:53400
Biological Process	GO:0033026	negative regulation of mast cell apoptotic process	IMP	J:101855
Biological Process	GO:0033033	negative regulation of myeloid cell apoptotic process	IGI	J:98325
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:120010
Biological Process	GO:0048541	Peyer's patch development	IGI	J:92679
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IGI	J:53400
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IGI	J:98326
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IDA	J:53400
Biological Process	GO:0045579	positive regulation of B cell differentiation	IGI	J:64603
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:98325
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:98325
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	IGI	J:92679
Biological Process	GO:0050729	positive regulation of inflammatory response	IGI	J:98325
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IGI	J:53400
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	IGI	J:92679
Biological Process	GO:0060376	positive regulation of mast cell differentiation	IMP	J:101855
Biological Process	GO:0070668	positive regulation of mast cell proliferation	IMP	J:101855
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IGI	J:53400
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IGI	J:77412
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	IMP	J:112035
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IMP	J:112035
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:101855
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:239212
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:77412
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98326
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:151963
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	IMP	J:63495
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IDA	J:98326
Biological Process	GO:0038026	reelin-mediated signaling pathway	ISO	J:260356
Biological Process	GO:0030155	regulation of cell adhesion	IMP	J:72801
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0030856	regulation of epithelial cell differentiation	IMP	J:72801
Biological Process	GO:0040014	regulation of multicellular organism growth	IGI	J:138238
Biological Process	GO:0019218	regulation of steroid metabolic process	IGI	J:95560
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:168252
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:92679
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:168252
Biological Process	GO:0043434	response to peptide hormone	IBA	J:265628
Biological Process	GO:0043434	response to peptide hormone	IDA	J:120010
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0033077	T cell differentiation in thymus	IGI	J:92679
Biological Process	GO:0043029	T cell homeostasis	IGI	J:53400
Biological Process	GO:0042098	T cell proliferation	IMP	J:101855
Biological Process	GO:0019530	taurine metabolic process	IGI	J:138238
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:98325
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:77412
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:98326