GO Annotations Graph

• Symbol: Stat3
• Name: signal transducer and activator of transcription 3
• ID: MGI:103038

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	ISO	J:155856
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:89612
Molecular Function	GO:0003677	DNA binding	IDA	J:99220
Molecular Function	GO:0003677	DNA binding	IDA	J:72970
Molecular Function	GO:0003677	DNA binding	IDA	J:84693
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:239159
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:223391
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:242717
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:89612
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:223391
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:245300
Molecular Function	GO:0042802	identical protein binding	IPI	J:248250
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0070878	primary miRNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:255328
Molecular Function	GO:0005515	protein binding	IPI	J:201284
Molecular Function	GO:0005515	protein binding	IPI	J:156583
Molecular Function	GO:0005515	protein binding	IPI	J:243387
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:136071
Molecular Function	GO:0005515	protein binding	IPI	J:175195
Molecular Function	GO:0005515	protein binding	IPI	J:177205
Molecular Function	GO:0005515	protein binding	IPI	J:187564
Molecular Function	GO:0005515	protein binding	IPI	J:201595
Molecular Function	GO:0005515	protein binding	IPI	J:222134
Molecular Function	GO:0005515	protein binding	IPI	J:131811
Molecular Function	GO:0005515	protein binding	IPI	J:159085
Molecular Function	GO:0005515	protein binding	IPI	J:187560
Molecular Function	GO:0005515	protein binding	IPI	J:245267
Molecular Function	GO:0005515	protein binding	IPI	J:200356
Molecular Function	GO:0005515	protein binding	IPI	J:103657
Molecular Function	GO:0005515	protein binding	IPI	J:64303
Molecular Function	GO:0005515	protein binding	IPI	J:206059
Molecular Function	GO:0005515	protein binding	IPI	J:163717
Molecular Function	GO:0005515	protein binding	IPI	J:84709
Molecular Function	GO:0005515	protein binding	IPI	J:99220
Molecular Function	GO:0005515	protein binding	IPI	J:99220
Molecular Function	GO:0005515	protein binding	IPI	J:68671
Molecular Function	GO:0005515	protein binding	IPI	J:223391
Molecular Function	GO:0005515	protein binding	IPI	J:84759
Molecular Function	GO:0005515	protein binding	IPI	J:89612
Molecular Function	GO:0005515	protein binding	IPI	J:223391
Molecular Function	GO:0005515	protein binding	IPI	J:89612
Molecular Function	GO:0005515	protein binding	IPI	J:111703
Molecular Function	GO:0046983	protein dimerization activity	IPI	J:72970
Molecular Function	GO:0046983	protein dimerization activity	IPI	J:72970
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:239159
Molecular Function	GO:0019901	protein kinase binding	IPI	J:148070
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:111703
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:175195
Cellular Component	GO:0005737	cytoplasm	IDA	J:190244
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:168575
Cellular Component	GO:0005737	cytoplasm	IDA	J:154112
Cellular Component	GO:0005737	cytoplasm	IDA	J:84693
Cellular Component	GO:0005737	cytoplasm	IDA	J:96322
Cellular Component	GO:0005737	cytoplasm	IDA	J:82697
Cellular Component	GO:0005737	cytoplasm	IDA	J:89612
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169142
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169206
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671836
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671854
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671877
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730597
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730598
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8950442
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676907
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676912
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9709373
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-8982998
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2730598
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9617215
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9618581
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9676907
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9705459
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9705472
Cellular Component	GO:0005634	nucleus	IDA	J:168575
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:175195
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:242717
Cellular Component	GO:0005634	nucleus	IDA	J:111703
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:89612
Cellular Component	GO:0005634	nucleus	IDA	J:86147
Cellular Component	GO:0005634	nucleus	IDA	J:99220
Cellular Component	GO:0005634	nucleus	IDA	J:188570
Cellular Component	GO:0005634	nucleus	IDA	J:82697
Cellular Component	GO:0005634	nucleus	IDA	J:208995
Cellular Component	GO:0005886	plasma membrane	IDA	J:86147
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:171795
Biological Process	GO:0006953	acute-phase response	IEA	J:60000
Biological Process	GO:0048708	astrocyte differentiation	IMP	J:175195
Biological Process	GO:0030154	cell differentiation	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IDA	J:99220
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:150450
Biological Process	GO:0032870	cellular response to hormone stimulus	ISO	J:164563
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:269278
Biological Process	GO:0044320	cellular response to leptin stimulus	ISO	J:164563
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:150450
Biological Process	GO:0019221	cytokine-mediated signaling pathway	NAS	J:114121
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0042755	eating behavior	IMP	J:89242
Biological Process	GO:0097009	energy homeostasis	IMP	J:82334
Biological Process	GO:0010467	gene expression	IMP	J:194832
Biological Process	GO:0042593	glucose homeostasis	IMP	J:82334
Biological Process	GO:0042593	glucose homeostasis	IMP	J:89242
Biological Process	GO:0060396	growth hormone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	IDA	J:143702
Biological Process	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IMP	J:239159
Biological Process	GO:0006954	inflammatory response	IMP	J:194832
Biological Process	GO:0038154	interleukin-11-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0030522	intracellular receptor signaling pathway	ISO	J:164563
Biological Process	GO:0033210	leptin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0033210	leptin-mediated signaling pathway	IMP	J:82334
Biological Process	GO:0033210	leptin-mediated signaling pathway	IDA	J:227387
Biological Process	GO:0033210	leptin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:223391
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:188570
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:188570
Biological Process	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IDA	J:249547
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	IDA	J:242717
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:2001223	negative regulation of neuron migration	IGI	J:195887
Biological Process	GO:2001223	negative regulation of neuron migration	IGI	J:195887
Biological Process	GO:2000635	negative regulation of primary miRNA processing	ISO	J:164563
Biological Process	GO:2000737	negative regulation of stem cell differentiation	IMP	J:223575
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IDA	J:242717
Biological Process	GO:0016310	phosphorylation	IDA	J:196462
Biological Process	GO:0045766	positive regulation of angiogenesis	IDA	J:250042
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:196462
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:239159
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:72970
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:223623
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	ISO	J:155856
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:1904685	positive regulation of metalloendopeptidase activity	ISO	J:164563
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:241064
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:2000637	positive regulation of miRNA-mediated gene silencing	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:175195
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:266673
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:211354
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:89612
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:99220
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:163717
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	IDA	J:250042
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	ISO	J:155856
Biological Process	GO:0006606	protein import into nucleus	ISO	J:164563
Biological Process	GO:0060019	radial glial cell differentiation	IMP	J:175195
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	TAS	J:114121
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:227387
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	NAS	J:114121
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0060259	regulation of feeding behavior	IMP	J:82334
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	ISO	J:155856
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:89242
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034097	response to cytokine	ISO	J:155856
Biological Process	GO:0032355	response to estradiol	ISO	J:164563
Biological Process	GO:0044321	response to leptin	IDA	J:227387
Biological Process	GO:0044321	response to leptin	IMP	J:82334
Biological Process	GO:0044321	response to leptin	ISO	J:164563
Biological Process	GO:0043434	response to peptide hormone	IBA	J:265628
Biological Process	GO:0060221	retinal rod cell differentiation	IMP	J:90895
Biological Process	GO:0019953	sexual reproduction	IMP	J:89242
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:164442
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	IMP	J:239159
Biological Process	GO:0072538	T-helper 17 type immune response	ISO	J:164563
Biological Process	GO:0001659	temperature homeostasis	IMP	J:89242
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:72970
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:111703
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:163717
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563