GO Annotations Graph

• Symbol: Stat4
• Name: signal transducer and activator of transcription 4
• ID: MGI:103062

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:79231
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:204817
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:131811
Molecular Function	GO:0005515	protein binding	IPI	J:181328
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:239213
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:75401
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9006466
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:79231
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:160369
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:79231
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:75401
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	IMP	J:232932
Biological Process	GO:0035722	interleukin-12-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070661	leukocyte proliferation	IDA	J:79231
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:189858
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:204817
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:151963
Biological Process	GO:0006468	protein phosphorylation	IDA	J:70821
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0043434	response to peptide hormone	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0045063	T-helper 1 cell differentiation	ISO	J:164563