GO Annotations Graph

• Symbol: Stat1
• Name: signal transducer and activator of transcription 1
• ID: MGI:103063

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:94130
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:326903
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:208171
Molecular Function	GO:0005515	protein binding	IPI	J:197978
Molecular Function	GO:0005515	protein binding	IPI	J:181328
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:164563
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:85994
Cellular Component	GO:0005737	cytoplasm	IDA	J:96405
Cellular Component	GO:0005737	cytoplasm	IDA	J:82697
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169142
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169206
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008004
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674908
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674931
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674959
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676907
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9676912
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0070721	ISGF3 complex	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9676907
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9705459
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9705472
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:85594
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:190006
Biological Process	GO:0008283	cell population proliferation	IGI	J:97143
Biological Process	GO:0008283	cell population proliferation	IGI	J:97143
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:150450
Biological Process	GO:0035458	cellular response to interferon-beta	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:173334
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:150450
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:288075
Biological Process	GO:0006351	DNA-templated transcription	IMP	J:94130
Biological Process	GO:0070106	interleukin-27-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0010742	macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0046725	negative regulation by virus of viral protein levels in host cell	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0034240	negative regulation of macrophage fusion	IMP	J:191592
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IDA	J:326903
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0061326	renal tubule development	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IDA	J:96405
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84896
Biological Process	GO:0035456	response to interferon-beta	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84896
Biological Process	GO:0043434	response to peptide hormone	IBA	J:265628
Biological Process	GO:0034340	response to type I interferon	IDA	J:222665
Biological Process	GO:0034341	response to type II interferon	ISO	J:164563
Biological Process	GO:0034341	response to type II interferon	IDA	J:326903
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IMP	J:197518
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IMP	J:219043
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	IMP	J:197518