GO Annotations Graph

• Symbol: Atrx
• Name: ATRX, chromatin remodeler
• ID: MGI:103067

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0140658	ATP-dependent chromatin remodeler activity	IEA	J:72247
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:93510
Molecular Function	GO:0031490	chromatin DNA binding	IBA	J:265628
Molecular Function	GO:0070087	chromo shadow domain binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0015616	DNA translocase activity	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	IPI	J:160497
Molecular Function	GO:0042393	histone binding	IDA	J:167956
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035064	methylated histone binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:158584
Molecular Function	GO:0005515	protein binding	IPI	J:158584
Molecular Function	GO:0005515	protein binding	IPI	J:304578
Molecular Function	GO:0005515	protein binding	IPI	J:209584
Molecular Function	GO:0005515	protein binding	IPI	J:37212
Molecular Function	GO:0005515	protein binding	IPI	J:91881
Molecular Function	GO:0005515	protein binding	IPI	J:125897
Molecular Function	GO:0005515	protein binding	IPI	J:171630
Molecular Function	GO:0005515	protein binding	IPI	J:37212
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0099115	chromosome, subtelomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:228107
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:160497
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:160497
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:225909
Cellular Component	GO:0000779	condensed chromosome, centromeric region	IDA	J:92329
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0000792	heterochromatin	IDA	J:91881
Cellular Component	GO:0000792	heterochromatin	IDA	J:86777
Cellular Component	GO:0000792	heterochromatin	IDA	J:125897
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0000228	nuclear chromosome	IDA	J:71817
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:125897
Cellular Component	GO:0005721	pericentric heterochromatin	IDA	J:160497
Cellular Component	GO:0005721	pericentric heterochromatin	IDA	J:92329
Cellular Component	GO:0005721	pericentric heterochromatin	IDA	J:225909
Cellular Component	GO:0016605	PML body	IDA	J:228107
Biological Process	GO:0072711	cellular response to hydroxyurea	IMP	J:209584
Biological Process	GO:0006325	chromatin organization	ISO	J:164563
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0070192	chromosome organization involved in meiotic cell cycle	IMP	J:92329
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	IMP	J:209584
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0030900	forebrain development	IMP	J:95953
Biological Process	GO:0000212	meiotic spindle organization	IMP	J:92329
Biological Process	GO:0035264	multicellular organism growth	IMP	J:209836
Biological Process	GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	ISO	J:164563
Biological Process	GO:0006334	nucleosome assembly	ISO	J:164563
Biological Process	GO:0010571	positive regulation of nuclear cell cycle DNA replication	IMP	J:209584
Biological Process	GO:0032206	positive regulation of telomere maintenance	IMP	J:160497
Biological Process	GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	ISO	J:164563
Biological Process	GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:171630
Biological Process	GO:0035128	post-embryonic forelimb morphogenesis	IMP	J:209836
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	IMP	J:160497
Biological Process	GO:0031297	replication fork processing	IMP	J:209584
Biological Process	GO:0031297	replication fork processing	IBA	J:265628
Biological Process	GO:0072520	seminiferous tubule development	IMP	J:171630
Biological Process	GO:0060009	Sertoli cell development	IMP	J:171630
Biological Process	GO:0007283	spermatogenesis	IMP	J:171630
Biological Process	GO:0031509	subtelomeric heterochromatin formation	IMP	J:167956
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:171630