GO Annotations Graph

• Symbol: Scn8a
• Name: sodium channel, voltage-gated, type VIII, alpha
• ID: MGI:103169

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:196238
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0031402	sodium ion binding	ISO	J:155856
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005248	voltage-gated sodium channel activity	NAS	J:51398
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0043194	axon initial segment	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0030425	dendrite	IDA	J:125694
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:121969
Cellular Component	GO:0043025	neuronal cell body	IDA	J:125694
Cellular Component	GO:0033268	node of Ranvier	IDA	J:77228
Cellular Component	GO:0033268	node of Ranvier	ISO	J:155856
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0034706	sodium channel complex	IPI	J:93341
Cellular Component	GO:0001518	voltage-gated sodium channel complex	ISO	J:155856
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IC	J:51398
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:127606
Biological Process	GO:0007628	adult walking behavior	IMP	J:27739
Biological Process	GO:0007626	locomotory behavior	IMP	J:84898
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0007517	muscle organ development	IMP	J:90095
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0009636	response to toxic substance	IDA	J:101093
Biological Process	GO:0007605	sensory perception of sound	IMP	J:108906
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0006814	sodium ion transport	NAS	J:51398
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247