GO Annotations Graph

• Symbol: Grb10
• Name: growth factor receptor bound protein 10
• ID: MGI:103232

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	IPI	J:149197
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0005158	insulin receptor binding	IBA	J:265628
Molecular Function	GO:0001784	phosphotyrosine residue binding	TAS	J:149197
Molecular Function	GO:0005515	protein binding	IPI	J:98784
Molecular Function	GO:0005515	protein binding	IPI	J:200357
Molecular Function	GO:0005515	protein binding	IPI	J:56881
Molecular Function	GO:0005515	protein binding	IPI	J:163129
Molecular Function	GO:0005515	protein binding	IPI	J:85099
Molecular Function	GO:0005515	protein binding	IPI	J:85099
Molecular Function	GO:0005515	protein binding	IPI	J:85099
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:51720
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	IPI	J:149197
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9654806
Cellular Component	GO:0005829	cytosol	TAS	J:50952
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:246383
Biological Process	GO:0010467	gene expression	IMP	J:246383
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IPI	J:85099
Biological Process	GO:0046325	negative regulation of glucose import	IMP	J:149197
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	TAS	J:149197
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IMP	J:149197
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0042326	negative regulation of phosphorylation	IDA	J:149197
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:163129
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:213603
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032868	response to insulin	ISO	J:155856
Biological Process	GO:0007165	signal transduction	TAS	J:51720
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	IMP	J:246383