GO Annotations Graph

• Symbol: Efna1
• Name: ephrin A1
• ID: MGI:103236

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:297316
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:297316
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:182367
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IDA	J:155186
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:166527
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	IMP	J:166527
Biological Process	GO:0048013	ephrin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:117343
Biological Process	GO:0048013	ephrin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:88877
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:91751
Biological Process	GO:0003183	mitral valve morphogenesis	IMP	J:166527
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	IDA	J:117343
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	IMP	J:166527
Biological Process	GO:0043409	negative regulation of MAPK cascade	IDA	J:129912
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IDA	J:129912
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:166527
Biological Process	GO:0030182	neuron differentiation	IDA	J:91751
Biological Process	GO:0014028	notochord formation	IGI	J:69393
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:91751
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0045765	regulation of angiogenesis	IDA	J:110334
Biological Process	GO:0050770	regulation of axonogenesis	IDA	J:88877
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	IDA	J:110334
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IDA	J:117343
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563