GO Annotations Graph

• Symbol: Calm2
• Name: calmodulin 2
• ID: MGI:103250

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010856	adenylate cyclase activator activity	ISO	J:164563
Molecular Function	GO:0008179	adenylate cyclase binding	ISO	J:164563
Molecular Function	GO:0019855	calcium channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	TAS	J:73397
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:306604
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	ISO	J:155856
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	ISO	J:155856
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	ISO	J:155856
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:306604
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0072542	protein phosphatase activator activity	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0031432	titin binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0031800	type 3 metabotropic glutamate receptor binding	ISO	J:155856
Cellular Component	GO:0034704	calcium channel complex	ISO	J:164563
Cellular Component	GO:1902494	catalytic complex	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:306604
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	IDA	J:240384
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0030017	sarcomere	ISO	J:164563
Cellular Component	GO:0005876	spindle microtubule	ISO	J:164563
Cellular Component	GO:0000922	spindle pole	ISO	J:164563
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IDA	J:306604
Cellular Component	GO:0008076	voltage-gated potassium channel complex	IGI	J:79145
Cellular Component	GO:0008076	voltage-gated potassium channel complex	IGI	J:79145
Biological Process	GO:0005513	detection of calcium ion	ISO	J:164563
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	IDA	J:73397
Biological Process	GO:1905913	negative regulation of calcium ion export across plasma membrane	IDA	J:306604
Biological Process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	IDA	J:306604
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:164563
Biological Process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:0050848	regulation of calcium-mediated signaling	IGI	J:306604
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0032465	regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:164563
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	IBA	J:265628
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563