GO Annotations Graph

• Symbol: Alk
• Name: anaplastic lymphoma kinase
• ID: MGI:103305

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:84931
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:73065
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISS	J:38743
Cellular Component	GO:0030424	axon	ISO	J:73065
Cellular Component	GO:0044297	cell body	ISO	J:73065
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISS	J:38743
Cellular Component	GO:0005886	plasma membrane	ISO	J:40563
Cellular Component	GO:0005886	plasma membrane	ISO	J:73065
Cellular Component	GO:0032991	protein-containing complex	ISO	J:194542
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0030534	adult behavior	IMP	J:226526
Biological Process	GO:0007420	brain development	IMP	J:226526
Biological Process	GO:0097009	energy homeostasis	IMP	J:291736
Biological Process	GO:0021766	hippocampus development	IMP	J:226526
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0050995	negative regulation of lipid catabolic process	IMP	J:291736
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0048666	neuron development	IEA	J:72247
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:1900006	positive regulation of dendrite development	IMP	J:281259
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043410	positive regulation of MAPK cascade	IEA	J:72247
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:73065
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:226526
Biological Process	GO:0060159	regulation of dopamine receptor signaling pathway	IMP	J:226526
Biological Process	GO:0045664	regulation of neuron differentiation	IBA	J:265628
Biological Process	GO:0090648	response to environmental enrichment	IMP	J:226526
Biological Process	GO:0006950	response to stress	IMP	J:226526
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0036269	swimming behavior	IMP	J:226526
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628