GO Annotations Graph

• Symbol: Tiam1
• Name: T cell lymphoma invasion and metastasis 1
• ID: MGI:103306

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:88877
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:88877
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IMP	J:192848
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	Reactome:R-NUL-9033341
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:82578
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	ISO	J:155856
Molecular Function	GO:0008017	microtubule binding	IDA	J:195272
Molecular Function	GO:0005543	phospholipid binding	IDA	J:82578
Molecular Function	GO:0005515	protein binding	IPI	J:192848
Molecular Function	GO:0005515	protein binding	IPI	J:192848
Molecular Function	GO:0005515	protein binding	IPI	J:156410
Molecular Function	GO:0005515	protein binding	IPI	J:192848
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:180470
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:155856
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0044291	cell-cell contact zone	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9033304
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9033333
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9033341
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0099147	extrinsic component of postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0060091	kinocilium	IDA	J:195272
Cellular Component	GO:0044304	main axon	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0000242	pericentriolar material	IDA	J:195272
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:82578
Cellular Component	GO:0005886	plasma membrane	IDA	J:193444
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032587	ruffle membrane	ISO	J:155856
Cellular Component	GO:0036477	somatodendritic compartment	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IBA	J:265628
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0090630	activation of GTPase activity	IMP	J:192848
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:155856
Biological Process	GO:0090630	activation of GTPase activity	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	IDA	J:180470
Biological Process	GO:0003300	cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:88877
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:1990138	neuron projection extension	ISO	J:155856
Biological Process	GO:0098989	NMDA selective glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050772	positive regulation of axonogenesis	ISO	J:155856
Biological Process	GO:0050772	positive regulation of axonogenesis	IBA	J:265628
Biological Process	GO:0050772	positive regulation of axonogenesis	IMP	J:88877
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	IDA	J:180470
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:1904268	positive regulation of Schwann cell chemotaxis	ISO	J:155856
Biological Process	GO:0072657	protein localization to membrane	ISO	J:155856
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0016601	Rac protein signal transduction	ISO	J:164563
Biological Process	GO:1904338	regulation of dopaminergic neuron differentiation	IMP	J:192848
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0043087	regulation of GTPase activity	IDA	J:180470
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:2000050	regulation of non-canonical Wnt signaling pathway	IGI	J:192848
Biological Process	GO:0099175	regulation of postsynapse organization	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007264	small GTPase mediated signal transduction	IBA	J:265628
Biological Process	GO:0007264	small GTPase mediated signal transduction	IDA	J:82578