Cxcl12 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cxcl12
C-X-C motif chemokine ligand 12
MGI:103556

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0008009	chemokine activity	IDA	J:79852
Molecular Function	GO:0042379	chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0045236	CXCR chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0045236	CXCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0008344	adult locomotory behavior	ISO	J:155856
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:98453
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:98453
Biological Process	GO:0007420	brain development	IDA	J:79852
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:98453
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:98453
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	IBA	J:265628
Biological Process	GO:0098609	cell-cell adhesion	IDA	J:178186
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:164563
Biological Process	GO:0038146	chemokine (C-X-C motif) ligand 12 signaling pathway	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0006935	chemotaxis	IEA	J:72247
Biological Process	GO:0006952	defense response	IEA	J:72247
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0071542	dopaminergic neuron differentiation	IDA	J:227463
Biological Process	GO:0007281	germ cell development	IDA	J:84597
Biological Process	GO:0008354	germ cell migration	IDA	J:84597
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0050930	induction of positive chemotaxis	IBA	J:265628
Biological Process	GO:0050930	induction of positive chemotaxis	IDA	J:84597
Biological Process	GO:0033622	integrin activation	ISO	J:164563
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:101029
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:101029
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:200277
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:200277
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:200277
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	ISO	J:164563
Biological Process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:1903237	negative regulation of leukocyte tethering or rolling	ISO	J:164563
Biological Process	GO:0001764	neuron migration	ISO	J:155856
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	ISO	J:155856
Biological Process	GO:0090280	positive regulation of calcium ion import	IDA	J:37252
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:200103
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0030335	positive regulation of cell migration	IDA	J:84597
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0050921	positive regulation of chemotaxis	IGI	J:200277
Biological Process	GO:0033603	positive regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI	J:200277
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:1901741	positive regulation of myoblast fusion	IMP	J:204300
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IGI	J:200277
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:200103
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0030334	regulation of cell migration	IGI	J:147597
Biological Process	GO:0030334	regulation of cell migration	IDA	J:79852
Biological Process	GO:0010818	T cell chemotaxis	ISO	J:164563
Biological Process	GO:0042098	T cell proliferation	IMP	J:82996
Biological Process	GO:0022029	telencephalon cell migration	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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