GO Annotations Graph

• Symbol: Hsd11b1
• Name: hydroxysteroid 11-beta dehydrogenase 1
• ID: MGI:103562

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	ISO	J:164563
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IBA	J:265628
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IDA	J:37226
Molecular Function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IMP	J:80523
Molecular Function	GO:0047022	7-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA	J:72245
Molecular Function	GO:0102196	cortisol dehydrogenase activity	IEA	J:72245
Molecular Function	GO:0050661	NADP binding	ISO	J:164563
Molecular Function	GO:0050661	NADP binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005496	steroid binding	ISO	J:155856
Molecular Function	GO:0005496	steroid binding	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031965	nuclear membrane	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Biological Process	GO:0006704	glucocorticoid biosynthetic process	ISO	J:155856
Biological Process	GO:0006713	glucocorticoid catabolic process	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0030324	lung development	IMP	J:80523
Biological Process	GO:0008212	mineralocorticoid metabolic process	ISO	J:155856
Biological Process	GO:0043456	regulation of pentose-phosphate shunt	ISO	J:155856
Biological Process	GO:0006706	steroid catabolic process	IBA	J:265628
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000