GO Annotations Graph

• Symbol: Hand2
• Name: heart and neural crest derivatives expressed 2
• ID: MGI:103580

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:153345
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:241318
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0070888	E-box binding	IDA	J:153345
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:160022
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:113904
Molecular Function	GO:0005515	protein binding	IPI	J:113904
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:92533
Molecular Function	GO:0005515	protein binding	IPI	J:102644
Molecular Function	GO:0005515	protein binding	IPI	J:92533
Molecular Function	GO:0005515	protein binding	IPI	J:80030
Molecular Function	GO:0005515	protein binding	IPI	J:92533
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:153345
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:153345
Molecular Function	GO:0043565	sequence-specific DNA binding	IGI	J:80030
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:153345
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	IPI	J:144188
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007813
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:144188
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:153345
Biological Process	GO:0007512	adult heart development	IMP	J:40768
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IMP	J:149232
Biological Process	GO:0003278	apoptotic process involved in heart morphogenesis	IMP	J:72600
Biological Process	GO:0055007	cardiac muscle cell differentiation	TAS	J:241318
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	IMP	J:155265
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP	J:160022
Biological Process	GO:0003219	cardiac right ventricle formation	IMP	J:65600
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	TAS	J:241318
Biological Process	GO:0060536	cartilage morphogenesis	IGI	J:128020
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0061325	cell proliferation involved in outflow tract morphogenesis	IMP	J:160022
Biological Process	GO:0060982	coronary artery morphogenesis	IMP	J:171088
Biological Process	GO:0061371	determination of heart left/right asymmetry	IMP	J:47294
Biological Process	GO:0042733	embryonic digit morphogenesis	IDA	J:80030
Biological Process	GO:0048706	embryonic skeletal system development	IGI	J:224515
Biological Process	GO:1904019	epithelial cell apoptotic process	IMP	J:149232
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IGI	J:94514
Biological Process	GO:0001947	heart looping	IMP	J:40768
Biological Process	GO:0003007	heart morphogenesis	IMP	J:72600
Biological Process	GO:0001701	in utero embryonic development	IMP	J:40768
Biological Process	GO:0010463	mesenchymal cell proliferation	IMP	J:149232
Biological Process	GO:0060485	mesenchyme development	IGI	J:128020
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP	J:155265
Biological Process	GO:0043392	negative regulation of DNA binding	IDA	J:144188
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:144188
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IMP	J:149232
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IDA	J:144188
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:144188
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0014032	neural crest cell development	IMP	J:49658
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:128020
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:144188
Biological Process	GO:0048935	peripheral nervous system neuron development	IDA	J:119859
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:80030
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:119859
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:2000764	positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis	IMP	J:155265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:153345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:160022
Biological Process	GO:2000763	positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process	IMP	J:155265
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:1903929	primary palate development	IMP	J:122604
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:92533
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation	IMP	J:155265
Biological Process	GO:0034103	regulation of tissue remodeling	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060021	roof of mouth development	IMP	J:122604
Biological Process	GO:0060021	roof of mouth development	IMP	J:149232
Biological Process	GO:0001967	suckling behavior	IMP	J:122604
Biological Process	GO:0048485	sympathetic nervous system development	IDA	J:119859
Biological Process	GO:0048538	thymus development	IMP	J:155265
Biological Process	GO:0043586	tongue development	IMP	J:122604
Biological Process	GO:0061032	visceral serous pericardium development	IMP	J:171088