Ptger4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ptger4
prostaglandin E receptor 4 (subtype EP4)
MGI:104311

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004957	prostaglandin E receptor activity	ISO	J:155856
Molecular Function	GO:0004957	prostaglandin E receptor activity	ISO	J:164563
Molecular Function	GO:0004957	prostaglandin E receptor activity	IBA	J:265628
Molecular Function	GO:0004957	prostaglandin E receptor activity	TAS	J:63070
Molecular Function	GO:0004955	prostaglandin receptor activity	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0044306	neuron projection terminus	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0031965	nuclear membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS	J:63070
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060348	bone development	ISO	J:155856
Biological Process	GO:0071260	cellular response to mechanical stimulus	IEP	J:182403
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	IBA	J:265628
Biological Process	GO:0042466	chemokinesis	ISO	J:155856
Biological Process	GO:0097070	ductus arteriosus closure	ISO	J:155856
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:63070
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0072639	interleukin-33 production	IMP	J:301363
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	ISO	J:155856
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:72198
Biological Process	GO:1904336	negative regulation of ductus arteriosus closure	ISO	J:155856
Biological Process	GO:1904471	negative regulation of endothelin production	ISO	J:155856
Biological Process	GO:2000420	negative regulation of eosinophil extravasation	ISO	J:164563
Biological Process	GO:0010727	negative regulation of hydrogen peroxide metabolic process	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:135247
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:135247
Biological Process	GO:0033624	negative regulation of integrin activation	ISO	J:164563
Biological Process	GO:0032690	negative regulation of interleukin-1 alpha production	ISO	J:155856
Biological Process	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	ISO	J:155856
Biological Process	GO:0002792	negative regulation of peptide secretion	ISO	J:155856
Biological Process	GO:1904348	negative regulation of small intestine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:2000388	positive regulation of antral ovarian follicle growth	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:155856
Biological Process	GO:1904364	positive regulation of calcitonin secretion	ISO	J:155856
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1904367	positive regulation of chemokinesis	ISO	J:155856
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO	J:155856
Biological Process	GO:0001819	positive regulation of cytokine production	IDA	J:151236
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:151236
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:155856
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:155856
Biological Process	GO:1904466	positive regulation of matrix metallopeptidase secretion	ISO	J:155856
Biological Process	GO:0070257	positive regulation of mucus secretion	ISO	J:155856
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	ISO	J:155856
Biological Process	GO:0045778	positive regulation of ossification	ISO	J:155856
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:2000386	positive regulation of ovarian follicle development	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:155856
Biological Process	GO:0035815	positive regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1904460	positive regulation of substance P secretion	ISO	J:155856
Biological Process	GO:1904496	positive regulation of substance P secretion, neurotransmission	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0035810	positive regulation of urine volume	ISO	J:155856
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:155856
Biological Process	GO:0010840	regulation of circadian sleep/wake cycle, wakefulness	ISO	J:155856
Biological Process	GO:0030278	regulation of ossification	IMP	J:63070
Biological Process	GO:0051492	regulation of stress fiber assembly	IDA	J:182403
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:98317
Biological Process	GO:0009624	response to nematode	IMP	J:301363
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0042093	T-helper cell differentiation	IDA	J:151236

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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