GO Annotations Graph

• Symbol: Tnfsf4
• Name: tumor necrosis factor (ligand) superfamily, member 4
• ID: MGI:104511

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005125	cytokine activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:247407
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	IPI	J:87166
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	IPI	J:26926
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Biological Process	GO:0002526	acute inflammatory response	IMP	J:164885
Biological Process	GO:0001568	blood vessel development	NAS	J:171783
Biological Process	GO:0035783	CD4-positive, alpha-beta T cell costimulation	IDA	J:162543
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NAS	J:169750
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0035714	cellular response to nitrogen dioxide	IMP	J:170014
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:8735
Biological Process	GO:0002215	defense response to nematode	IMP	J:127284
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IPI	J:87166
Biological Process	GO:0045087	innate immune response	NAS	J:164885
Biological Process	GO:0035709	memory T cell activation	IMP	J:127284
Biological Process	GO:0070236	negative regulation of activation-induced cell death of T cells	IC	J:71803
Biological Process	GO:0001818	negative regulation of cytokine production	IPI	J:87166
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:26926
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:26926
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IC	J:71803
Biological Process	GO:0032700	negative regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	IMP	J:138954
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	IC	J:71803
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	IDA	J:169814
Biological Process	GO:0032689	negative regulation of type II interferon production	IDA	J:169814
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:155856
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	IMP	J:131079
Biological Process	GO:0050871	positive regulation of B cell activation	IDA	J:169814
Biological Process	GO:1900281	positive regulation of CD4-positive, alpha-beta T cell costimulation	IDA	J:162543
Biological Process	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	IDA	J:162543
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:169800
Biological Process	GO:0002699	positive regulation of immune effector process	TAS	J:138954
Biological Process	GO:0002891	positive regulation of immunoglobulin mediated immune response	IMP	J:127284
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IDA	J:26926
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:164885
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:164885
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IDA	J:169884
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:155856
Biological Process	GO:0032753	positive regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IDA	J:169814
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IDA	J:169884
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IMP	J:127284
Biological Process	GO:2000572	positive regulation of interleukin-4-dependent isotype switching to IgE isotypes	IMP	J:127284
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:164885
Biological Process	GO:2000568	positive regulation of memory T cell activation	IMP	J:127284
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	IDA	J:138954
Biological Process	GO:2000525	positive regulation of T cell costimulation	IDA	J:162543
Biological Process	GO:0002726	positive regulation of T cell cytokine production	IDA	J:169814
Biological Process	GO:0002726	positive regulation of T cell cytokine production	IDA	J:169884
Biological Process	GO:2000406	positive regulation of T cell migration	NAS	J:169814
Biological Process	GO:2000570	positive regulation of T-helper 2 cell activation	IMP	J:127284
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IDA	J:169884
Biological Process	GO:0002830	positive regulation of type 2 immune response	IMP	J:127284
Biological Process	GO:0002830	positive regulation of type 2 immune response	IDA	J:169884
Biological Process	GO:0002830	positive regulation of type 2 immune response	IMP	J:152054
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:138954
Biological Process	GO:0002819	regulation of adaptive immune response	IDA	J:164885
Biological Process	GO:0050727	regulation of inflammatory response	IDA	J:169800
Biological Process	GO:0035713	response to nitrogen dioxide	IDA	J:170014
Biological Process	GO:0009615	response to virus	IDA	J:162543
Biological Process	GO:0042098	T cell proliferation	ISO	J:155856
Biological Process	GO:0035712	T-helper 2 cell activation	IMP	J:127284