GO Annotations Graph

• Symbol: Tnfrsf4
• Name: tumor necrosis factor receptor superfamily, member 4
• ID: MGI:104512

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:44894
Molecular Function	GO:0005515	protein binding	IPI	J:169068
Molecular Function	GO:0005515	protein binding	IPI	J:117429
Molecular Function	GO:0005515	protein binding	IPI	J:26926
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IBA	J:265628
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IPI	J:87166
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:118845
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:58979
Biological Process	GO:0006968	cellular defense response	IMP	J:58979
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IPI	J:87166
Biological Process	GO:0006954	inflammatory response	IMP	J:87871
Biological Process	GO:0070236	negative regulation of activation-induced cell death of T cells	IMP	J:71803
Biological Process	GO:0001818	negative regulation of cytokine production	IPI	J:87166
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:26926
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:26926
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IMP	J:71803
Biological Process	GO:0030890	positive regulation of B cell proliferation	IMP	J:26926
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IDA	J:26926
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:87871
Biological Process	GO:0045859	regulation of protein kinase activity	IMP	J:87871
Biological Process	GO:0042098	T cell proliferation	ISO	J:155856